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ABO Incompatible and Positive Crossmatch Kidney Transplants

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Dr. Mark Stegall, Kidney and Pancreas Transplant Surgeon at Mayo Clinic in Rochester, MN, discusses antibody barriers to successful kidney transplantation.

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Abo incompatible kidney transplant Mayo Clinic Mark Stegall sensitized patient paired exchange alloantibody deceased donor positive crossmatch ABO Big Mad abo ABOS a-bo Abo's conflicting inappropriate incongruous inconsistent irreconcilable unsuitable unsuited uncongenial adverse antipathetic antipodal antithetical clashing contrary counter disagreeing discordant discrepant disparate factious inadmissible incoherent inconformable inconsonant inconstant jarring mismatched night and day offbeat opposed opposite poles apart unadapted warring whale of difference appropriate consistent fitting harmonious proper suitable compatible consonant loving suited alien estranged exotic extraneous extrinsic incompatible remote separate unusual native normal familiar akin usual antagonistic at odds with contrariant disconsonant dissonant incongruent opposing paradoxical unfavorable unmixable agreeable peaceful contradictory against agin anti antipodean antithetic con converse counteractive diametric negating no go ornery polar repugnant reverse reconcilable confirming same equal reconciled agreeing similar at odds cacophonous contrarient different divergent grating harsh inharmonious on a sour note quarreling strident unharmonious unmelodious concordant cooperating at variance differing diverse varying concurring contrasting dissimilar distant distinct far cry incommensurate like night and day unalike unequal unequivalent uneven unlike unsimilar various uniform like alike along with also as a consequence as well as furthermore including moreover together with additionally and plus again along as well besides conjointly further in conjunction with in like manner likewise more more than that on top of over and above still to boot too withal added amassed another augmented bounteous deeper else enhanced exceeding expanded extended extra farther fresh heavier higher in addition increased innumerable larger major massed new numerous other spare supplementary too many wider fewer less Big Mad And? And's clear conclusive confident decisive specific absolute affirmative cold concrete express firm perfect rank real actual assured categorical clear-cut cocksure complete consummate convinced decided direct downright explicit factual forceful forcible genuine hard inarguable incontestable incontrovertible indisputable indubitable irrefutable out-and-out outright sure thorough thoroughgoing unambiguous undeniable unequivocal unmistakable unmitigated indefinite uncertain vague flawed flexible imperfect imprecise yielding disadvantageous doubtful negative unhelpful unsure good useful effective constructive practical productive reasonable sound progressive efficacious forward-looking impractical unproductive incapable impotent fruitless worthless useless unskilled Panglossian bright buoyant cheerful cheering encouraged expectant happy high hopeful hoping idealistic keeping the faith merry on cloud nine on top of world positive promising ray of sunshine rose-colored roseate rosy sanguine sunny trusting upbeat utopian definite exact fixed infallible precise unquestionable partial dependent limited false conditional submissive compliant complaisant tractable restricted accountable incorrect inexact questionable equivocal ambiguous authentic certain confirmed for real honest injun honest to God kosher physical realistic substantial substantive sure enough tangible true truthful verified past nominal legendary mental unfixed theoretical reputed hypothetical unreal pretended imaginary fictitious counterfeit spiritual acknowledging acquiescent affirmatory affirming approving complying concurring confirmative confirmatory confirming consenting corroborative endorsing favorable supporting dissenting assertive demanding dogmatic domineering emphatic forward insistent militant overbearing pushy self-assured self-confident strong-willed unconfident shy quiet diffident meek audacious bold brazen collected complacent composed cool gung ho gutsy imperturbable overconfident poised puffed up pumped up secure self-possessed unflappable unhesitating fearful dismayed confused doubted humble modest dubious nervous hesitant doubting distrustful feared excited agitated timid worried upset Positive Big Mad Positives bravery caliber courage fortitude grit spunk stamina temperament animation ardor backbone daring dauntlessness disposition energy fire force gallantry gameness guts hardihood heart indomitability life makeup moxie nature nerve pluck quality resolution resolve spirit stamp starch temper valor vigor vitality cowardice timidity weakness apathy dullness fear idleness inactivity indecision lethargy powerlessness question mettle position line place set family grade rank species slot estate breed pigeonhole hierarchy station branch feather type sort description degree stripe genre kind ilk cast bracket genus caste pecking order subclass taxonomic group license mess disorder confusion unemployment answer liberty lawlessness muddle disorganization order category brand character strain assortment division classification tribe make class race uniformity variety marrow stomach tongue tripe brains chitlins chitterlings giblets gizzard kidneys liver mountain oyster pancreas prairie oyster sweetbread testis thymus variety meat collection province domain frame selection standing mold section status denomination grouping source sect school league style department origin color sphere rate humor suit property name designation value range grain distinction end effect whole result misrepresentation kidney classes descriptions Big Mad Kidney emigrate graft immigrate remove uproot displace move readapt recondition reorient reset resettle revamp shift transfer transpose plant remain sow stay preserve save carries backpack bear bring cart channel conduct convey convoy ferry fetch freight funnel give haul heft hoist import lift lug pack pipe portage relay relocate schlepp shoulder sustain take tote traject transmit transplant truck waft lose fail leave maintain receive lower drop stop fix keep hold shun dodge avoid refuse carry carrying colonize conquer found migrate people pioneer colonized colonizing Big Mad Transplant transplants Transplants ABO Big Mad abo ABOS a-bo Abo's conflicting inappropriate incongruous inconsistent irreconcilable unsuitable unsuited uncongenial adverse antipathetic antipodal antithetical clashing contrary counter disagreeing discordant discrepant disparate factious inadmissible incoherent inconformable inconsonant inconstant jarring mismatched night and day offbeat opposed opposite poles apart unadapted warring whale of difference appropriate consistent fitting harmonious proper suitable compatible consonant loving suited alien estranged exotic extraneous extrinsic incompatible remote separate unusual native normal familiar akin usual antagonistic at odds with contrariant disconsonant dissonant incongruent opposing paradoxical unfavorable unmixable agreeable peaceful contradictory against agin anti antipodean antithetic con converse counteractive diametric negating no go ornery polar repugnant reverse reconcilable confirming same equal reconciled agreeing similar at odds cacophonous contrarient different divergent grating harsh inharmonious on a sour note quarreling strident unharmonious unmelodious concordant cooperating at variance differing diverse varying concurring contrasting dissimilar distant distinct far cry incommensurate like night and day unalike unequal unequivalent uneven unlike unsimilar various uniform like alike bravery caliber courage fortitude grit spunk stamina temperament animation ardor backbone daring dauntlessness disposition energy fire force gallantry gameness guts hardihood heart indomitability life makeup moxie nature nerve pluck quality resolution resolve spirit stamp starch temper valor vigor vitality cowardice timidity weakness apathy dullness fear idleness inactivity indecision lethargy powerlessness question mettle position line place set family grade rank species slot estate breed pigeonhole hierarchy station branch feather type sort description degree stripe genre kind ilk cast bracket genus caste pecking order subclass taxonomic group license mess disorder confusion unemployment answer liberty lawlessness muddle disorganization order category brand character strain assortment division classification tribe make class race uniformity variety marrow stomach tongue tripe brains chitlins chitterlings giblets gizzard kidneys liver mountain oyster pancreas prairie oyster sweetbread testis thymus variety meat collection province domain frame selection standing mold section status denomination grouping source sect school league style department origin color sphere rate humor suit property name designation value range grain distinction end effect whole result misrepresentation kidney classes descriptions Big Mad Kidney emigrate graft immigrate remove uproot displace move readapt recondition reorient reset resettle revamp shift transfer transpose plant remain sow stay preserve save carries backpack bear bring cart channel conduct convey convoy ferry fetch freight funnel give haul heft hoist import lift lug pack pipe portage relay relocate schlepp shoulder sustain take tote traject transmit transplant truck waft lose fail leave maintain receive lower drop stop fix keep hold shun dodge avoid refuse carry carrying colonize conquer found migrate people pioneer colonized colonizing Big Mad Transplant transplants Transplants Mayo Clinic Big Mad mayo Big Mad Mayo hospital dispensary infirmary sick bay surgery center faculties academics advisers body clinic college corps department employees institute literati mentors organization personnel professorate profs researchers scholars society staff university workers students need ineptness lack incompetence inability faculty hospice asylum emergency room health service institution nursing home rest home sanatorium sanitarium shelter surgery ward hospitals academy association business company conservatory establishment fixture foundation guild orphanage school seminar seminary system think tank Big Mad Clinic impression imprint line point record scar score signature spot stain stamp streak symbol autograph blaze blot blotch brand bruise check cross dent dot ink label logo nick pock register representation scratch sign smudge splotch stroke tag ticket trace trademark underlining John Hancock John Henry brand name blank clarity unimportance marking hallmark attribute image evidence peculiarity seal quality particularity index character feature note print type emblem trait virtue device earmark incision badge token indication idiosyncrasy distinction property affection proof significant indicia level yardstick gauge norm measure function duty use end object aim prey purpose ambition objective result value effect standing dignity notice regard influence notability manifestation consequence eminence prestige fame neglect cause insignificance inferiority ignorance heedlessness lowliness source impress underline pinpoint initial write inscribe letter chalk lose smooth mend signify show indicate identify demonstrate illustrate evince exemplify remark exhibit individualize proclaim singularize betoken bespeak qualify manifest distinguish signalize denote designate check off point out show up individuate mark off ostend point up set apart stake out cover confuse hide conceal observe attend eye chronicle watch mind perceive hearken behold discern view pay attention pay heed take notice of write down overlook look away disbelieve disregard ignore endorsement inscription mark undersignature address consign dispatch forward postmark remit route send ship superscribe transmit pass receive retain keep hold slight shun cut avoid addressed addresses addressing aspiration course desideratum design desire direction intent intention plan scheme target where one is heading wish thoughtlessness avoidance hatred hate dislike Mark Big Mad sharpen animate excite refine deaden allergic affected averse to dyspathetic hypersensitive immune sensitive sensitive sensitized susceptible calm forgiving gentle quiet tolerant long-suffering understanding accommodating composed easy-going enduring even-tempered forbearing imperturbable indulgent lenient meek mild mild-tempered persevering persistent philosophic philosophical resigned self-possessed serene stoical submissive tranquil uncomplaining unruffled untiring agitated loud rough troubled violent wild frustrated impatient intolerant unwilling inmate case victim subject convalescent emergency invalid sufferer shut-in outpatient sick person doctor aloof amiable amicable civil collected cool as cucumber cool-headed detached disinterested dispassionate equable impassive inscrutable kind laid-back levelheaded listless moderate neutral patient placid pleased poised relaxed restful satisfied sedate still temperate unconcerned undisturbed unemotional unexcitable unexcited unflappable unimpressed unmoved untroubled ruffled roused passionate mad furious turbulent uncontrolled unreasonable worried excitable angry stormy frenzied fierce biased unfriendly excited excessive immoderate upset nervous calmer client applicant believer buyer chump consumer dependent disciple follower front habitué head mark patron protégé protégée purchaser shopper walk-in ward marketer owner rear manager clients considerate attentive benevolent big charitable chivalrous circumspect compassionate complaisant concerned cool discreet generous kindly like a sport magnanimous mellow mindful obliging polite solicitous sympathetic tactful tender thoughtful unselfish warmhearted unmindful scornful uncareful thoughtless harsh hard careless rude mean disagreeable unfeeling disrespectful rash indiscreet incautious inconsiderate uncharitable inattentive heedless hateful stingy selfish greedy unsympathetic uncaring merciless easygoing amenable breezy carefree casual devil-may-care flexible free and easy hang-loose happy-go-lucky indolent informal insouciant lazy liberal low-pressure nonchalant offhand outgiving uncritical undemanding unhurried uninhibited strict hyped critical hurried demanding planned deliberate Big Mad Patient dichotomized double binary binate doubled dual paired twice singular single lone complementary commutual complemental completing completory conclusive correlative correspondent corresponding crowning equivalent fellow integral integrative interconnected interdependent interrelated interrelating matched parallel reciprocal different unrelated independent dissimilar as much again bifold coupled dualistic duple duplex duplicate duplicated geminate repeated second twin twofold binal doubleheader joined accompanying affiliated affixed akin allied associated attached banded blended bracketed cemented cognate combined confederated conjoined connected entwined federated fused inseparable interallied interclasped interfused intermixed intertwined involved married merged mingled mixed put together related stuck together touching unified united wedded apart uncombined separated disparate disconnected Paired change commerce network swap transaction transfer barter castling commutation conversion correspondence dealing interchange interdependence interrelation rearrangement reciprocation reciprocity replacement revision shift shuffle shuffling substitution switch traffic transposition truck buying and selling quid pro quo supplantment tit for tat stagnation market stock exchange net curb store Wall Street over the counter the Big Board the Street replace seesaw commute correspond invert alternate reciprocate flip-flop substitute shuttle bandy transpose displace rearrange reverse bargain castle transact revise change hands buy and sell cash in contact with convert into deal in give and take go over to hook up horse trade link up pass to pay back return the compliment swap horses turn the tables continue hold keep leave alone remain refuse deny alteration about-face accommodation adaptation adjustment amendment correction difference diversification exchange fixing metamorphosis mid-course correction modification mutation reformation remodeling reshaping switch-over transformation transmutation turn variance variation agreement sameness act reciprocally alter blow hot and cold come and go fill in for fluctuate follow follow in turn intersperse oscillate relieve rotate shilly-shally sway vacillate vary waver yo-yo stay persist alternated alternating argument argumentation assertion case claim contention debate defense discussion expostulation grounds line of reasoning logic plea pleading polemic proof questioning reason reasoning remonstrance remonstration arguments Ex-change Big Mad exchanges departed cold expired finished former gone lost asleep defunct exanimate extinct gave up the ghost inanimate late lifeless passed on pushing up daisies current existing present alive born lively living bodies ashes bones cadaver carcass carrion clay corpus delicti dead body deceased dust relic remains stiff one thought immateriality spirit soul mind individual nothingness nothing fantasy concept abstract body cage corpse mort skeleton being dead bereft of life bloodless bought the farm breathless buried cadaverous checked out cut off done for erased gone to meet maker gone to reward inert mortified no more not existing offed passed away perished reposing resting in peace spiritless unanimated wasted animate warm active subsisting live existent unfinished incomplete enduring continuing working operative spirited responsive interested animated bygone down the drain had it inoperative invalid kaput nonexistent obsolete out of commission vanished operating valid functioning Deceased backer benefactor contributor patron almsgiver altruist angel benefactress bestower conferrer grantor philanthropist presenter savior subscriber Santa Claus donator heavy hitter antagonist opponent opposer donor friend giver sponsor supporter detractor enemy contributors Good Samaritan bleeding heart do-gooder good scout helper attester endorser signer Donor Big Mad clear conclusive confident decisive specific absolute affirmative cold concrete express firm perfect rank real actual assured categorical clear-cut cocksure complete consummate convinced decided direct downright explicit factual forceful forcible genuine hard inarguable incontestable incontrovertible indisputable indubitable irrefutable out-and-out outright sure thorough thoroughgoing unambiguous undeniable unequivocal unmistakable unmitigated indefinite uncertain vague flawed flexible imperfect imprecise yielding disadvantageous doubtful negative unhelpful unsure good useful effective constructive practical productive reasonable sound progressive efficacious forward-looking impractical unproductive incapable impotent fruitless worthless useless unskilled Panglossian bright buoyant cheerful cheering encouraged expectant happy high hopeful hoping idealistic keeping the faith merry on cloud nine on top of world positive promising ray of sunshine rose-colored roseate rosy sanguine sunny trusting upbeat utopian definite exact fixed infallible precise unquestionable partial dependent limited false conditional submissive compliant complaisant tractable restricted accountable incorrect inexact questionable equivocal ambiguous authentic certain confirmed for real honest injun honest to God kosher physical realistic substantial substantive sure enough tangible true truthful verified past nominal legendary mental unfixed theoretical reputed hypothetical unreal pretended imaginary fictitious counterfeit spiritual acknowledging acquiescent affirmatory affirming approving complying concurring confirmative confirmatory confirming consenting corroborative endorsing favorable supporting dissenting assertive demanding dogmatic domineering emphatic forward insistent militant overbearing pushy self-assured self-confident strong-willed unconfident shy quiet diffident meek audacious bold brazen collected complacent composed cool gung ho gutsy imperturbable overconfident poised puffed up pumped up secure self-possessed unflappable unhesitating fearful dismayed confused doubted humble modest dubious nervous hesitant doubting distrustful feared excited agitated timid worried upset Positive Big Mad Positives
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