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Bone Marrow Stem Cell Treatment (BMAC) for Knee Osteoarthritis - Mayo Clinic

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Shane Shapiro, M.D., orthopedic physician at Mayo Clinic in Florida, discusses a regenerative medicine clinical research trial to treat knee arthritis, which is the ...

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Mayo Clinic (Organization) Health Care (Issue) MayoClinicFL MSC osteoarthritis arthritis Mayo Clinic Center for Regenerative Medicine Shane Shapiro BMAC Regenerative Medicine Clinical Trial (Literature Subject) Joint Replacement (Medical Treatment) Orthopedic Surgery (Medical Specialty) Harvesting Stem Cells Knee Arthritis (Disease Or Medical Condition) Bone Marrow (Anatomical Structure) Stem Cell (Field Of Study) Knee (Anatomical Structure) Pain ossein anklebone astragalus bone talus tarsus altercation beef bickering blowup bone of contention bone to pick brannigan brawl brush clash controversy crusher debate difference of opinion disagreement dispute donnybrook dustup exchange face-off falling feud finisher flap fuss gin hassle knock down and drag out knockdown out quarrel rhubarb romp row ruckus ruction rumpus run-in scene scrap set-to shindy spat squabble static stew talking heads tiff words wrangle chase debit draw upon dun figure invoice put the arm on put the bite on put the squeeze on reckon record render solicit clinker conflict contention denial difference disaccord discord dissension dissidence disunity far cry flak heresy heterodoxy misbelief nonagreement nonconcurrence nonconformism nonconformity nope objection opposition poles apart protest refusal resistance schism sour note split strife unorthodoxy variance chops jowl mandible maxilla mouth muzzle orifice back chine rachis ridge spinal column vertebrae vertebral column ankle argument bill dissent jaw spine bones Bones kernel meat core bottom soul pith stuff quick cream spirit gist exterior outside character entity essence essentia essentiality individuality marrow personality quintessence self substance texture basis bottom line cause ground heart mainspring origin principle root source virtuality axis bull's-eye centrality centriole centrum cynosure equidistance focal point focus hotbed hub inside interior intermediacy mainstream middle of the road midpoint midst nave navel nucleus omphalos pivot place polestar radial point seat aspect attribute backbone base be-all and end-all being burden caliber chief constituent constitution crux element fiber form fundamentals germ grain life lifeblood main idea meaning name of game nature nitty-gritty nub point property quality quiddity reality structure timber vein bearing drift force idea import keynote matter name of the game nature of the beast nitty gritty nuts and bolts punch line score sense short significance subject summary tenor theme thrust topic upshot basic bosom center coal and ice middle trunk shoot stock axis root derive emanate arise head develop proceed spring rise flow issue be bred cease cause abet aid end halt stop help hinder withstand resist curb contain restrain control dam stay arrest oppose check hold back appear begin come to light commence crop up emerge ensue follow happen occur originate result set in start stem arbor axle hinge pivot pole shaft spindle stalk support turning point gudgeon mandrel pin rod antecedent birth conception egg embryo font fount fountain fountainhead generation genesis germ heart principle resource seed well beak bowsprit fore forepart nose prow accrue derive from ejaculate end up hail from turn out beginning bow come from STEM Stems stems Stem germ egg unit embryo spore cage crib booth crypt nook pen coop vault hole hold keep stall den tower alcove antechamber apartment bedchamber bedroom box case cavity cell chest container cubicle enclosure flat hall hollow lodging pocket room socket abbey chapter house convent friary hermitage house lamasery monastery nunnery order priorate priory religious community retreat sanctuary area bay berth carrel carriage category chamber corner cubbyhole department division locker niche part piece pigeonhole place portion slot catacomb cave cavern compartment grave grotto mausoleum sepulcher tomb undercroft desk office work area oubliette torture chamber cloister dungeon Cell regimen remedy cure therapy surgery healing diet harm hurt conduct method habit custom manner way usage angle line mode dealing advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benefit benevolence bounty care charity comfort compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement relief rescue reward salvation service shot in the arm subsidy sustenance treatment administering administration applying creaming dosing oiling rubbing TLC awareness big rush brace concern consciousness looking after notice observation recognition regard spotlight tender loving care carrying on channels charge control direction execution handling intendance leadership management manipulation organization oversight plan policy posture red tape regulation rule running strategy superintendence supervision tactics transaction wielding aid antidote catholicon corrective counteractant counteragent countermeasure drug elixir elixir vitae fix healing agent help medicament medicant medication medicine nostrum panacea pharmacon physic placebo proprietary quick fix recovery redress reparation restora-tive therapeutic architecture arrangement blueprint chart comp composition conception constitution construction delineation depiction diagram doodle drawing dummy form formation idea layout makeup map model outline paste-up pattern perspective picture scheme study tracery tracing application design being now since after during pro toward to go to as long as cause considering for for the reason that inasmuch as seeing that whereas as a result of as things go by cause of by reason of by virtue of due to for the sake of in as much as in behalf of in that in the interest of in view of now that on the grounds that over owing to seeing thanks to through backing in agreement on the side of supporting all in all all things considered because everything being equal forasmuch as in consideration of in light of insomuch as pending taking into account accept advocate appreciate approbate approve back be in favor of be on one's side buck for champion choose commend cotton to countenance encourage endorse esteem eulogize fancy flash on go for hold with honor incline lean toward look up to opt for patronize pick praise prize regard highly root for sanction single out support take a liking to take a shine to take to think well of tilt toward value accordingly and so consequently ergo for this reason hence in consequence in that event on account of on the grounds then thence therefrom thereupon thus to that end whence wherefore behind favor therefore FOR patella bend corner crook crotch cusp decline divergence dogleg edge elbow flare flection flexure fork incline intersection knee nook notch obliquity point slant turn turning twist articulation axis ball-and-socket butt hook joint juncture link pin spring swivel alliance annexation assemblage attachment bond coalition coherence collocation combination combine concatenation concourse concursion confluence conjugation consolidation convergence coupling crossing crossroads dovetail gathering gore hinge hookup interface joining linking meeting miter mortise node pivot plug-in reunion seam splice terminal tie-in tie-up union weld angle junction knees Knee Knees Mayo mayo hospital infirmary sick bay dispensary academics advisers body clinic college corps department employees institute instructors lecturers literati mentors organization pedagogues personnel professorate professors profs researchers scholars society staff tutors university workers emergency room health service hospice institution nursing home rest home sanatorium sanitarium surgery ward academy association asylum business company conservatory establishment fixture foundation guild orphanage school seminar seminary system think tank shelter faculty Clinic energy fitness verdure tone shape pink fettle stamina state vigor form bloom prime disease illness appearance aspect build constitution health kilter mint order phase repair status trim bliss dreamland ecstasy elation exaltation exhilaration exultation frenzy glee high spirits intoxication joy joyousness jubilation madness rapture relaxation transport good health robustness strength anatomy being condition figure frame object outline person phenomenon physique silhouette thing torso advantage big break blessing break fluke fortunateness godsend good luck happiness in the cards karma kismet luckiness lucky break occasion opportunity profit prosperity run of luck serendipity smile streak of luck stroke success triumph victory weal wealth win windfall agreement assurance covenant guarantee oath promise toast undertaking vow warrant word euphoria luck pledge Health HEALTH load strain fear worry charge woe dismay sorrow onus burden stress alarm sweat bother stew health aid relief joy delight calm benefit comfort help peace ease neglect effort wariness caution concern nicety interest exertion regard prudence trouble thought heed pains apathy laziness lethargy disregard ignorance omission oversight control trust keeping aegis ward watch tend protect attend sit mind foster mother nurse nurture wait on hate hurt enjoy love want cherish desire respect like prize take to amore ardor attachment care case closeness crush devotion emotion endearment feeling friendliness friendship good will hankering heart inclination itch kindness liking passion predilection propensity puppy love sentiment shine soft spot solicitude tenderness warmth weakness yen advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benevolence bounty charity compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement rescue reward salvation service shot in the arm subsidy sustenance treatment all-overs angst ants in pants apprehension botheration butterflies cold sweat creeps disquiet disquietude distress doubt downer drag dread fidgets flap foreboding fretfulness fuss goose bumps heebie-jeebies jitters jumps misery misgiving mistrust nail-biting needles nervousness panic pins and needles restlessness shakes shivers suffering suspense uncertainty unease uneasiness watchfulness willies worriment amenity assiduities civility compliment consideration deference gallantry mindfulness politeness authority countenance influence sponsorship supervision affection anxiety attention(s) auspices Care cares care? MSC msc arthritis Arthritis Art-hritis inside midway mean deepest inmost inner medial mid outer edging heart place hub kernel essence focus seat pivot midst axis interior core gist midpoint nucleus marrow pith quick root nave omphalos polestar hotbed cynosure centrum navel margin rim border edge town city plaza club mall station capital market mart meet attract gather unify collect join focalize close on disjoin scatter divide arsenal center depot dump factory headquarters magazine plant range camp dock field garrison hangar harbor home port post settlement site starting point strip terminal antecedent assumption authority axiom backbone background backing base bedrock cause chief ingredient crux data dictum essential evidence explanation footing fundamental hard fact infrastructure justification keynote keystone law nexus postulate premise presumption presupposition principal element principle proof reason rudiment sanction security source substratum support theorem theory underpinning warrant affections circle conscience emotions feelings sentiments soul spirit sympathies Capitol Hill dome legislative hall political scene seat of government statehouse axial basic cardinal centric centroidal chief dominant equidistant focal foremost important intermediate key leading master median middle middlemost midmost nuclear omphalic outstanding overriding paramount pivotal predominant primary prime radical ruling salient significant umbilical armory basis bosom capitol central artistic helpful humane learned liberal refined refining edifying adorning raising widening advancing beautifying beneficial broadening civilizing constructive corrective developmental dignifying disciplining educative elevating ennobling enriching expanding glorifying humanizing influential inspirational instructive liberalizing nurturing ornamenting polishing promoting regenerative socializing stimulating uplifting cultural drug remedy cure pill balm salve dose tablet physic tonic potion lotion capsule elixir serum vaccine disease analysis biology cytology diagnosis dissection division embryology etiology examination genetics histology inquiry investigation medicine morphology physiology zoology antitoxin antivenin corrective counteractant counteragent countermeasure counterstep negator neutralizer nullifier preventive antibiotic antibody antipoison antiseptic antiserum analgesic application balsam cerate compound cream demulcent dressing embrocation emollient formula ointment poultice preparation prescription soother soothing agent unction unguent aid alleviation antidote assistance catholicon elixir vitae fix healing healing agent help medicament medicant medication nostrum panacea pharmacon placebo proprietary quick fix recovery redress reparation restora-tive therapeutic treatment biologic depressant dope essence medicinal narcotic opiate pharmaceutic pharmaceutical poison sedative stimulant anatomy Medicine Shane shapiro Shapiro bmac BMAC BMac Bmac cold feeling aloof bystanding calm clinical collected cool detached disengaged disinterested dispassionate easy evenhanded fair-minded impersonal inactive indifferent inert middle-of-road nonaligned nonbelligerent nonchalant noncombatant nonparticipating nonpartisan on sidelines on the fence pacifistic poker-faced relaxed unaligned unbiased uncommitted unconcerned undecided uninvolved unprejudiced impartial neuter neutral Clinical test pilot known proven testing struggle probation effort essay lick shot shakedown hassle endeavor check crack whack assay fling workout audition stab attempt analysis try venture tryout proof dry run trial run try on showcase striving R and D test run peace case suit hearing contest action lawsuit claim seizure rap ordeal load anguish blow woe sorrow pain bane plague burden care grief bother drag pest misery rigor thorn calvary health aid relief joy calm favor profit help cheer ease conclusive test crucial test decisive test definitive test experiment genuineness proving ground substantiation sure test test of value trial verification affliction bad break bummer calamity can of worms catastrophe clutch contretemps crunch difficulty disaster distress downer evil eye hard knocks hard times hardship hurting ill fortune jam jinx kiss of death misfortune mishap on the skids pain in the neck poison reverse suffering the worst tough luck trouble adversity cross crux depression disease disorder illness infirmity plight scourge sickness torment tribulation bill of indictment charge citation denunciation impeachment indictment prosecution summons appraisal assessment estimation evaluation examination inspection investigation measurement rating survey valuation all one's got attack bid exertion header one's all one's darnedest one's level best pursuit undertaking acid test arraignment Trials trials public united joined common communal mutual conjoint conjunct divided separate disjoint single unshared elbow seam bridge splice point nexus bend union tie meeting node swivel crux link knot hinge bracket suture bond hyphen copula whole divorce line tavern club bar dive address apartment base casa co-op condo crash pad crib den digs domicile dwelling flat flop habitat haunt headquarters hearth hole home homestead house joint lodging pad quarters residence roost sanctuary seat affiliated agnate akin amalgamated associated bound cognate combined confederate connate connected in league incident kindred linked married related unified wed coupling joining junction juncture unification adapter clamp connection connector fastener beef up carve clean cure cut cut down dress liquidate salt slaughter smoke stick Monte Carlo bank betting house big store clubhouse dance hall dice joint gambling den hall honky-tonk pool hall roadhouse rotunda saloon track abode allied articulation attachment butcher casino joints stand-in predecessor backup double equivalent fill-in proxy replacement sub surrogate agent alternate ambassador appointee catchpole commissioner consul deputy emissary envoy factor front legate member member of Congress minister mouthpiece nominee people's choice pinch hitter plenipotentiary regent rep senator spokesperson substitute vicar viceroy aide assembly member councilor delegate dogcatcher lieutenant representant representative second-in-command subordinate barter buying and selling castling change commerce commutation conversion correspondence dealing interchange interdependence interrelation network quid pro quo rearrangement reciprocation reciprocity revision shift shuffle shuffling substitution supplanting supplantment swap switch tit for tat traffic transaction transfer transposing transposition truck expediency expedient last resort pis aller recourse refuge resort resource stopgap adjustment darn improvement mend new part overhaul patch reconstruction reformation rehabilitation exchange makeshift repair replacements Replacement section incision aciurgy clinic emergency room health service hospice infirmary institution nursing home rest home sanatorium sanitarium sick bay surgery ward biopsy excision analysis cure diet doctoring healing hospitalization medication medicine operation prescription regimen remedy therapeutics therapy operating table operating theater asylum shelter care rehabilitation hospital treatment operating room rehab Surgery harvest reaping agriculture agronomics agronomy breeding crop-raising cultivation culture feeding fertilizing gardening geoponics gleaning grazing growing harvesting homesteading hydroponics landscaping operating production ranching seeding share-cropping soil culture threshing tillage autumn by-product consequence cropping effect fall fruitage fruition garnering gathering harvest-time ingathering intake output produce repercussion result return season storing summer yield yielding beating flailing separating sifting treading winnowing breed crop dress farm fertilize garden labor manage mature plant plow prepare propagate raise ripen seed tend till work bore break up bulldoze burrow cat channel clean concave deepen depress dig down discover dredge drill drive enter excavate exhume fork out go into gouge grub hoe investigate mine penetrate pierce pit probe quarry root root out rout sap scoop scoop out search shovel sift spade tunnel turn over uncover undermine unearth acquire attain bag be entitled to be worthy of come by gain merit net rate reap score warrant win farming cultivate dig earn Harvesting germ egg unit embryo spore cage crib booth crypt nook pen coop vault hole hold keep stall den tower beef brawn cells corpuscles fat fatness flesh and blood food meat muscle plasm plasma protoplasm sinews thews weight alcove antechamber apartment bedchamber bedroom box case cavity cell chest container cubicle enclosure flat hall hollow lodging pocket room socket abbey chapter house convent friary hermitage house lamasery monastery nunnery order priorate priory religious community retreat sanctuary area bay berth carrel carriage category chamber corner cubbyhole department division locker niche part piece pigeonhole place portion slot catacomb cave cavern compartment grave grotto mausoleum sepulcher tomb undercroft desk office work area flesh cloister Cell arthritis Arthritis Art-hritis curative healing iatric iatrical harmful hurting tonic sedative narcotic salutary peptic aesculapian curing medical medicative pharmaceutic remedial therapeutic medicinal Medical cramp fever burn agony wound strain misery twinge ache injury spasm malady crick prick stitch throb gripe sting hurt tingle pang catch throe joy aid peace ease help cheer shock grief woe worry rack effort bother drag pest bore harm distress afflict agonize grieve rile torment vex gall suffer anguish injure convulse bite irritate nick irk smart annoy disquiet torture sadden punish inflame aggrieve harrow chafe stress chasten upset ail harass mend calm heal fix cure be sore pain pound beset burden crucify harry lacerate martyr oppress pester plague press smite strike trouble try adversity calamity cross crux depression difficulty disease disorder hardship illness infirmity misfortune ordeal plight scourge sickness sorrow suffering trial tribulation affliction aggro botheration exasperation hang-up headache irksomeness irritation pain in the neck pet peeve provocation teasing vexation bleed carry on disturb eat heart out excruciate labor lament sing the blues squirm stew over strive struggle take it badly wince writhe sicken aggravation Pain
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