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Dr. Goldberg on PD-1 Blockade in Tumors with Mismatch Repair Deficiency

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Richard Goldberg, MD, interim division director, Medical Oncology, physician-in-chief, Ohio State University Comprehensive Cancer Center-James Cancer ...

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cancer oncology DNA Mismatch Repair Tumor (Disease Or Medical Condition) Programmed Cell Death 1 (Protein) Colorectal Cancer (Disease Or Medical Condition) STEMlord D.R. Dr. goldberg STEMlord Goldberg barricade closure encirclement restriction roadblock siege stoppage bar clog embolus hindrance impediment infarct infarction obstacle obstruction snag stop wall blank wall beginning opening start advantage aid assistance clearance help promotion support block blockade bolt caulk close dam deadbolt dike fasten fence jam latch lock plug seal secure trammel allow loose let go unstop unclog open free unplug unfasten permit advocate unseal release loosen unblock unlock barred barrier bulwark palisade rampart stockade defend fortify obstruct shut in barricaded bound boundary confines curtain ditch enclosure fortification gully hurdle limit moat pale railing trench Blockade STEMlord cancer carcinoma cyst lump swelling bump neoplasm sarcoma tumefaction boil abscess blain blister carbuncle excrescence furuncle pimple pustule sore tumor ulcer bulb ball bunch corm corn globe head knob nodule nub protuberance tuber depression bulge appendage bagginess blob convexity dilation distention excess gibbosity growth hump intumescence jut nodulation outgrowth outthrust projection prominence promontory protrusion sac sagging salience salient superfluity tuberosity wart lack big C canker corruption disease long illness malignancy sickness wholesomeness benignity health bulk doorknob knot knurl latch lever opener snag stud swell trigger agglomeration bit block cake chip chunk cluster crumb dab gob group handful hunk lot morsel mountain much nugget part peck piece pile portion scrap section solid spot tumescence wad wedge one little individual whole STEMlord Tumors along alongside amidst among beside for including near plus upon accompanying concomitant with additionally also as companion as well at same time besides coupled with furthermore in addition to likewise moreover side by side simultaneously too far separate apart by all of by the whole of in association with in connection with in the class of in the company of mutually out of together with with one another outside away from a step from abreast of adjacent to adjoining aside at the edge of at the side of bordering on cheek by jowl close at hand close to close upon connected with contiguous to fornent in juxtaposition nearby neck and neck neighboring next door to nigh opposite overlooking round verging on at the hand of in the name of over supported by through through the agency of through the medium of under the aegis of via with the assistance of along with among other things as well as counting in conjunction with inclusive of made up of not to mention rejecting excluding W.I.T.H. STEMlord WITH discrepancy imbalance disproportion dissimilarity divergence divergency diverseness incongruity inequality unevenness dissemblance imparity balance equality evenness sameness similarity clash be dissimilar conflict contrast differ disaccord discord disharmonize mismatch not go with match agree clashes brawl bump heads with collide combat contend contest cross swords with disagree disturb fight interfere jar lock horns with oppose romp run against tide scrap slug square off with strive struggle tangle vary be calm support yield help make peace give up assist aid surrender retreat harmonize consent conflicted conflicts be a foil to be contrary to be diverse be unlike be variable bracket collate contradict depart deviate differentiate distinguish diverge hang hold a candle to match up separate set in opposition set off stack up against stand out weigh conform accord join stay concur coincide STEMlord adjustment improvement overhaul reconstruction rehabilitation replacement darn mend patch reformation substitution new part breaking damage destruction harm hurt injury neglect wrecking revive rectify rebuild heal refurbish renovate revamp retrieve remedy recover correct improve sew right rejuvenate reform square doctor refresh renew settle redress debug emend recondition do up patch up touch up compensate for retread fiddle with give a face-lift make good make up for put back together put in order put right stay maintain spoil kill upset decline break remain wreck weaken injure worsen ruin destroy remove fare run proceed recur turn process travel move resort journey hie withdraw pass apply wend refer betake oneself head for push on set off for stop halt wait cease adjust align balance bring into line calibrate connect fine-tune fit fix focus grind improve accommodate polish put in working order readjust regulate repair service set sharpen tighten troubleshoot tune up unfit confuse dull disorder disarrange derange disorganize adjusted adjusting adjusts amend alter ameliorate better change elevate enhance help lift modify raise revise reduce debase drop depress lower subtract mar impair corrupt blemish lessen ignore decrease amended STEMlord dearth defect failing failure fault flaw frailty glitch insufficiency lack scarcity shortage shortcoming weakness absence bug defalcation default deficit demerit dereliction loss need neglect paucity privation scantiness sin want inability to hack it insufficience abundance advantage enough excess perfection plenty strength strong point success sufficiency surplus accomplishment achievement adequacy faultlessness satisfaction superfluity Achilles' heel chink in the armor deficiency handicap soft underbelly susceptibility drought inadequacy omission unavailability void presence existence arrears back payment balance due claim debit liability obligation unpaid bill blind spot drawback weak point exiguousness famine infrequency meagerness miss poverty rareness scantness slim pickings sparsity uncommonness plentifulness wealth luxury blemish blunder delinquency disregard error imperfection lapse nonpayment offense overlooking oversight slight transgression vice wrongdoing regard right correction respect care attention remembrance payment accuracy obedience STEMlord corruption disease malignancy sickness tumor canker carcinoma big C long illness health wholesomeness benignity Cancer STEMlord cancer oncology STEMlord RNA chromosome gene heredity genetic code nucleic acid DNA STEMlord Dna dna cancer carcinoma cyst lump swelling bump neoplasm sarcoma tumefaction boil abscess blain blister carbuncle excrescence furuncle pimple pustule sore tumor ulcer bulb ball bunch corm corn globe head knob nodule nub protuberance tuber depression bulge appendage bagginess blob convexity dilation distention excess gibbosity growth hump intumescence jut nodulation outgrowth outthrust projection prominence promontory protrusion sac sagging salience salient superfluity tuberosity wart lack big C canker corruption disease long illness malignancy sickness wholesomeness benignity health bulk doorknob knot knurl latch lever opener snag stud swell trigger agglomeration bit block cake chip chunk cluster crumb dab gob group handful hunk lot morsel mountain much nugget part peck piece pile portion scrap section solid spot tumescence wad wedge one little individual whole STEMlord Tumors medicinal pharmaceutical preventive therapeutic cathartic curative disinfectant narcotic prophylactic restorative sedative tonic alleviating pathological peptic salutary healing corrective aesculapian iatric iatrical medicative therapeutical hurting injurious harmful curing medical pharmaceutic remedial STEMlord Medical compute prioritize register set up arrange bill book budget calculate compile design draft edit engage enter estimate feed figure formulate itemize list poll prearrange process schedule set slate get on line lay on lay out line up map out pencil in work out cancel disorder disorganize disperse forget let go scatter neglect automated automatic computerized electrical electronic mechanical mechanized motorized programmed robotic by hand manual cybernated digital indoctrinated brainwashed persuaded cold cursory emotionless fixed habitual impersonal instinctive involuntary laborsaving lifeless machine-driven matter-of-fact monotonous perfunctory routine spiritless standardized stereotyped unchanging unconscious unfeeling unthinking useful feeling conscious planned in the making on the docket outlined prepared prospective bacterium egg germ unit corpuscle embryo follicle microorganism spore utricle vacuole cellule haematid chamber apartment cage cubicle recess crib booth receptacle dungeon closet cavity crypt nook pen burrow compartment lockup coop alcove vault hole hold retreat keep stall den cloister tower antechamber bastille bedchamber bedroom box case cell chest container enclosure flat hall hollow lodging pocket room socket abbey chapter house convent friary hermitage house lamasery monastery nunnery order priorate priory religious community sanctuary area bay berth carrel carriage category corner cubbyhole department division locker niche part piece pigeonhole place portion slot whole catacomb cave cavern grave grotto mausoleum sepulcher tomb undercroft desk office work area oubliette torture chamber STEMlord Cell afterlife annihilation bereavement casualty cessation curtains darkness decease demise departure destruction dissolution downfall dying end ending eradication euthanasia exit expiration extermination extinction fatality finis finish grave heaven loss mortality necrosis obliteration oblivion paradise parting passing quietus release repose ruin ruination silence sleep termination tomb eternal rest Grim Reaper passing over accomplishment arrival beginning birth building coming commencement consciousness construction creation entrance hell initiation introduction opening start success understanding being entity existence life living bitter end completion conclusion death end of life end of the line lights out doom Judgment Day Moira calamity cataclysm catastrophe circumstance condemnation decree destination destiny disaster fixed future foreordination fortune handwriting on wall judgment karma kismet lap of the gods lot opinion portion predestination predetermination sentence tragedy verdict way the ball bounces way the cookie crumbles wonder good fortune blessing whole accusation miracle happiness good luck boon adieu egress egression evacuation exodus expiry farewell going goodbye leave-taking offgoing retirement retreat stampede withdrawal entering arriving hello stay close closing terminus inception elimination no life obsolescence thing of the past STEMlord Death corruption disease malignancy sickness tumor canker carcinoma big C long illness health wholesomeness benignity Cancer STEMlord cancer
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