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Immune Function Marker Does Not Predict Benefit of Trastuzumab in HER+ Breast Cancer Patients

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Dr. Edith Perez, deputy director at large, Mayo Clinic Cancer Center, and director of the Breast Cancer Translational Genomics Program at Mayo Clinic in Florida ...

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Mayo Clinic (Organization) Health Care (Issue) Healthcare Science (Field Of Study) News release Florida news release Mayo Clinic in Florida breast cancer Edith Perez HER2+ breast cancer trastuzumab Herceptin Mayo Clinic Cancer Center 2014 San Antonio Breast Cancer Symposium triple negative breast cancer MayoClinicFL Health Care (Industry) exempt clear safe free favored allowed unguarded hindered absolved beat the rap cleared discharged excepted excluded excused immune let go let off liberated not liable not responsible not subject off the hook outside privileged released set apart spared special unbound unchecked unrestrained unrestricted unshackled void of walked closed to hermetic impassable impassive impenetrable impermeable imperviable inaccessible invulnerable resistant sealed tight unaffected unapproachable unmoved unpierceable unreceptive watertight authorized chartered eligible empowered entitled franchised furnished granted kosher legit licensed okay okayed palatine qualified sanctioned vested dedicated defended guarded inviolable inviolate sacrosanct secure shielded untouchable impregnable out of harm's way protected riskless sheltered unassailable undamaged unharmed camouflaged cared for cherished covered disguised ensconced fostered guaranteed harbored preserved safeguarded secured shaded impervious sacred duty affair task power work action part role use target office goal object mark charge post fun pastime inertia party react operate serve behave run move cook take act do duty cease fail idle lose halt stop stay accomplish achieve begin carry on carry out consummate create develop do a number do one's thing enforce execute function get in there go about go for broke go for it go in for go that route go to town intrude knock off labor make progress maneuver officiate percolate perk perpetrate persevere persist practice preside pursue respond take effect take part take steps take up transort undertake work out appear carry carry oneself comport conduct enact exert give the appearance impress as perform play part represent oneself seem strike take on entertainment gathering reception shindig soiree appliance appositeness employment exercise exercising germaneness operation pertinence play purpose relevance usance utilization value bag biz calling career craft dodge field game line livelihood métier occupation pursuit racket specialty trade vocation what one is into assignment beeswax carrying on goings-on hanky-panky happening interest issue lookout matter palaver point problem question responsibility subject topic application business Function colored pen marking pen stone pole flag rag notch arrow peg guide brand cordon device identification insignia mark marker medallion motto pin ribbon scepter shield sign stamp symbol token brand name emblem hallmark heraldry imprint logo logotype trademark welt beacon drift float signal adumbration arms attribute badge banner character coat of arms colophon colors design figure image impress medal memento miniature monogram pennant regalia reminder representation seal standard type ABCs Bible bellwether catalog chapter and verse clue compendium directory enchiridion guidebook guiding light handbook hot lead key landmark lodestar manual no-no's pointer print signpost telltale the book the numbers tip-off vade mecum code ground rule guidance instruction precept protocol rule standard procedure buoy guideline markers Marker move execute end complete prepare conclude perform make work finish determine produce undertake act close operate succeed create achieve organize fix effect discharge cook fulfill cause transact arrange pull off take on wind up wrap up engage in get ready go for it see to ignore ruin stop bear fail forget miss begin start halt lose idle defer pass undo satisfy answer serve avail suffice suit resolve render decode adapt quit play go on appear give manage conduct carry present fare portray comport seem demean deport enact get by put on playact take cover track tour beat fleece dupe hoax bilk trick deceive gyp con cozen defraud swindle chouse offer arrive attain bring about bring off carry out consummate do a bang-up job do justice do one proud do the trick gain get someplace get there hit make hay make it nail it put it over rack up reach realize score sew up take care of win accomplish acquire actualize bring to pass cap carry through deliver dispatch earn earn wings effectuate follow through get get done negotiate obtain perfect procure seal see through settle sign solve work out carry on develop do a number do one's thing enforce function get in there go about go for broke go in for go that route go to town intrude knock off labor make progress maneuver officiate percolate perk perpetrate persevere persist practice preside pursue respond take effect take part take steps take up transort behave carry oneself exert give the appearance impress as play part react represent oneself strike clarify conform correlate correspond crack deal with dope dope out elucidate fill fit lick measure up meet qualify unzip work through affect caricature copy counterfeit ditto do like echo emulate go like imitate impersonate make like mirror mock parody parrot take off travesty ape D.O 'do D.O. no more nix nay not not at all not either never neither NOT foresee envision conclude anticipate forecast call think figure prophesy portend vaticinate surmise guess forebode presage infer conjecture read adumbrate foretell presume judge omen gather suppose augur croak telegraph be afraid call it figure out forespeak make book psych out see coming size up soothsay ignore measure forerun foreshow harbinger herald indicate predict signal signify allocate apportion calculate compute cost estimate ration approximate make rough guess place prognosticate put reckon regard apprehend deduce discern forefeel foreknow go out on a limb intuit perceive previse see see in the cards suspect take a shot take a stab understand visualize behold conceive conceptualize contemplate externalize fancy feature form mental picture of grasp have a picture of image imagine look upon materialize objectify realize survey think up view view in mind's eye vision account appraise assay assess believe budget calculate roughly cast cipher class classify consider count decide determine enumerate evaluate examine expect form opinion gauge guesstimate look into number outline plan rank rate reason run over scheme set a figure sum tax think through announce divine envisage PREDICT Predict use help profit perk gain welfare aid asset account good gravy avail favor boon godsend worth cream extras loss hurt injury harm stop exhibit raffle ball concert fair dance dinner bazaar pay assist serve better succor build block halt afford arrange benefit bow comfort convenience defer furnish gratify humor indulge oblige pamper please provide settle submit suit supply support sustain yield accomplishment achievement allowance annuity award bonus commission dividend donation earnings fortune gift grant income increment inheritance net premium prize proceeds remuneration return reward riches salary security wages wealth winnings agreement allotment apportionment compensation compromise reconciliation reimbursement settlement share stake stipulation adduce allege ballyhoo beat the drum for boost cite encourage foster further get ink for hype introduce lay forward make a pitch for offer plug present proffer puff push put forward put on the map set forth splash spot suggest throw spotlight on urge advancement advice advocacy alleviation assistance attention backing backup benefaction benevolence bounty care charity cooperation deliverance encouragement endowment furtherance giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement relief rescue salvation service shot in the arm subsidy sustenance treatment blessing credit distinction resource treasure accommodate acquisition adjustment advance benefits Benefit 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health Cancer bane blight blister boil corrosion corruption lesion rot scourge smutch sore ulcer affliction burden calamity cross disaster evil evil eye hydra jinx ordeal pestilence plague torment tribulation trouble vexation voodoo ache affection attack breakdown bug canker collapse complaint condition contagion contamination convulsions debility decrepitude defect disorder distemper endemic epidemic feebleness fever fit flu hemorrhage ill health illness indisposition infection infirmity inflammation malady misery pathosis seizure sickliness sickness spell stroke syndrome temperature unhealthiness unsoundness upset virus visitation cancroid excrescence fibrous tissue fibrousness fungus lump mole outgrowth parasite polyp swelling thickening wen ailment disability aggravation besetment blast bother botheration exasperation irritant nuisance pain pest problem thorn in side trial curse disease growth cancer inmate case victim doctor career clients patients profession vocation work applicant believer buyer chump consumer dependent disciple follower front habitué head mark patient patron protégé protégée purchaser shopper walk-in ward consumptive convalescent incurable shut-in sufferer bedlamite crazy person demented deranged idiot imbecile loon lunatic maniac mental case psycho psychopath psychotic raver schizophrenic sociopath client customer guinea pig liege national serf subordinate vassal cuckoo dement loony madman madwoman nut nutcase oddball screwball practice invalid mad person subject madperson Mayo mayo hospital infirmary sick bay dispensary academics advisers body clinic college corps department employees institute instructors lecturers literati mentors organization pedagogues personnel professorate professors profs researchers scholars society staff tutors university workers emergency room health service hospice institution nursing home rest home sanatorium sanitarium surgery ward academy association asylum business company conservatory establishment fixture foundation guild orphanage school seminar seminary system think tank shelter faculty Clinic energy fitness verdure tone shape pink fettle stamina state vigor form bloom prime disease illness appearance aspect build constitution health kilter mint order phase repair status trim bliss dreamland ecstasy elation exaltation exhilaration exultation frenzy glee high spirits intoxication joy joyousness jubilation madness rapture relaxation transport good health robustness strength anatomy being condition figure frame object outline person phenomenon physique silhouette thing torso advantage big break blessing break fluke fortunateness godsend good luck happiness in the cards karma kismet luckiness lucky break occasion opportunity profit prosperity run of luck serendipity smile streak of luck stroke success triumph victory weal wealth win windfall agreement assurance covenant guarantee oath promise toast undertaking vow warrant word euphoria luck pledge Health HEALTH load strain fear worry charge woe dismay sorrow onus burden stress alarm sweat bother stew health aid relief joy delight calm benefit comfort help peace ease neglect effort wariness caution concern nicety interest exertion regard prudence trouble thought heed pains apathy laziness lethargy disregard ignorance omission oversight control trust keeping aegis ward watch tend protect attend sit mind foster mother nurse nurture wait on hate hurt enjoy love want cherish desire respect like prize take to amore ardor attachment care case closeness crush devotion emotion endearment feeling friendliness friendship good will hankering heart inclination itch kindness liking passion predilection propensity puppy love sentiment shine soft spot solicitude tenderness warmth weakness yen advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benevolence bounty charity compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement rescue reward salvation service shot in the arm subsidy sustenance treatment all-overs angst ants in pants apprehension botheration butterflies cold sweat creeps disquiet disquietude distress doubt downer drag dread fidgets flap foreboding fretfulness fuss goose bumps heebie-jeebies jitters jumps misery misgiving mistrust nail-biting needles nervousness panic pins and needles restlessness shakes shivers suffering suspense uncertainty unease uneasiness watchfulness willies worriment amenity assiduities civility compliment consideration deference gallantry mindfulness politeness authority countenance influence sponsorship supervision affection anxiety attention(s) auspices Care cares care? Health care Healthcare Health Care art system skill lore branch wisdom ignorance disorder ability accomplishment address aestheticism capacity civilization class courtesy cultivation delicacy dignity discrimination dress elegance elevation enlightenment erudition experience fashion finish gentility good taste grace improvement kindness learning manners nobility perception polish politeness practice proficiency refinement savoir-faire science tact training urbanity apprenticeship background book learning brainwashing breeding catechism coaching culture direction discipline drilling edification guidance inculcation indoctrination information learnedness literacy nurture pedagogy preparation propagandism proselytism reading rearing scholarship schooling study teaching tuition tutelage tutoring bookishness brains intellectuality knowledge letters pedantry savvy scholarliness studiousness advice ammo break chapter and verse clue confidence counsel cue data dirt dope dossier earful illumination info inside story instruction intelligence leak lowdown material message network notice notification orientation propaganda report scoop score tidings tip what's what whole story word accomplishments acquaintance apprehension attainments awareness cognition comprehension consciousness discernment doctrine dogma education expertise facts familiarity goods grasp insight judgment know-how light observation philosophy picture power principles recognition substance theory acquirements literature research SCIENCE! Science bulletin handout dispatch announcement news release newsworthy item notice release statement press release story word advice account report message data rumor hearsay telegram tidings dispatch telecast scandal leak telling copy cable recital scoop release bulletin exposé lowdown silence truth history admonition advisement advocacy aid bum steer caution charge consultation counsel directions dissuasion encouragement exhortation forewarning guidance help information injunction input instruction judgment lesson news opinion persuasion prescription proposal proposition recommendation steer suggestion teaching telltale tip tip-off two cents' worth view warning word to the wise advertisement briefing broadcast broadcasting communication communiqué disclosure dissemination divulgence edict exposing exposition expression intimation narration notice notification prediction promulgation publication publishing recitation reporting revelation statement announcement break calendar flash handout hot wire item list news flash program skinny the dope what's going down what's happening comment cry grapevine rumble scuttlebutt talk whisper conversation converse declaration directive excerpt goods hot story ideas info inside story intelligence language missive note pipeline poop prophecy précis publicity speech summary translation utterance work buzz NEWS clemency freeing spring liberty charge commute relief freedom turnout lifeboat walkout floater let-off hold check issue leak notice flash story news secret truth clear drop deliver free vent loosen unloose unfasten acquit untie exempt dispense loose undo excuse unbind absolve yield unleash manumit liberate bail out give off let off turn out unchain give out open up set free take out unfetter limit detain fasten blame keep retain bind gather acquittal amnesty compurgation exculpation forgiveness mercy pardon release bleach blink at discharge exculpate exonerate forgive go easy on launder let off easy let off the hook let up on relieve sanitize spare vindicate whitewash wink at wipe it off wipe the slate clean write off disculpate let go wipe off absolution acquitting clearance deliverance discharging dismissal dismissing exemption exoneration letting off liberation releasing relief from reprieve vindication accord accredit admit approve authorize be big be game for bear brook certify commission consent empower endorse endure favor free up give a blank check give carte blanche give leave give permission give the go-ahead give the green light go along with grant permission hear of hold with indulge let license live with oblige okay pass pass on put up with recognize sanction sit still for stand suffer support take kindly to tolerate warrant advertise annunciate blast blazon broadcast call communicate declare disclose disseminate divulge drum impart intimate make known make public pass the word proclaim promulgate propound publicize publish report reveal run off at mouth sound off spread around state tell trumpet allow announce Florida florida Flo Rida story word advice account report message data rumor hearsay telegram tidings dispatch telecast scandal leak telling copy cable recital scoop release bulletin exposé lowdown silence truth history admonition advisement advocacy aid bum steer caution charge consultation counsel directions dissuasion encouragement exhortation forewarning guidance help information injunction input instruction judgment lesson news opinion persuasion prescription proposal proposition recommendation steer suggestion teaching telltale tip tip-off two cents' worth view warning word to the wise advertisement briefing broadcast broadcasting communication communiqué disclosure dissemination divulgence edict exposing exposition expression intimation narration notice notification prediction promulgation publication publishing recitation reporting revelation statement announcement break calendar flash handout hot wire item list news flash program skinny the dope what's going down what's happening comment cry grapevine rumble scuttlebutt talk whisper conversation converse declaration directive excerpt goods hot story ideas info inside story intelligence language missive note pipeline poop prophecy précis publicity speech summary translation utterance work buzz NEWS Breast Cancer chest bosom front bust nipple udder teat heart core being mind soul psyche spirit emotions thoughts body breast mammary glands peritoneum pulmonary cavity rib cage ribs thorax upper trunk anterior bow brow exterior facade face facing façade fore foreground forehead forepart front line frontage frontal frontispiece head lead obverse proscenium top van vanguard belly bowels center contents gut innards inner portion interior recess stuffing womb anima animating principle animation animus ardor bottom breath of life cause conscience courage disposition ego elan vital essence feeling fervor force genius individuality intellect intelligence life marrow nobility noumenon personality pith pneuma principle quintessence reason recesses of heart secret self spiritual being stuff substance thought vital force vitality vivacity élan vital cockles of the heart deepest mind heart of hearts inmost heart inmost mind inmost soul inner self inner woman mind's core subconscious inside inner man breasts health Cancer bane blight blister boil corrosion corruption lesion rot scourge smutch sore ulcer affliction burden calamity cross disaster evil evil eye hydra jinx ordeal pestilence plague torment tribulation trouble vexation voodoo ache affection attack breakdown bug canker collapse complaint condition contagion contamination convulsions debility decrepitude defect disorder distemper endemic epidemic feebleness fever fit flu hemorrhage ill health illness indisposition infection infirmity inflammation malady misery pathosis seizure sickliness sickness spell stroke syndrome temperature unhealthiness unsoundness upset virus visitation cancroid excrescence fibrous tissue fibrousness fungus lump mole outgrowth parasite polyp swelling thickening wen ailment disability aggravation besetment blast bother botheration exasperation irritant nuisance pain pest problem thorn in side trial curse disease growth cancer Edith edith Perez inside midway mean deepest inmost inner medial mid outer edging heart place hub kernel essence focus seat pivot midst axis interior core gist midpoint nucleus marrow pith quick root nave omphalos polestar hotbed cynosure centrum navel margin rim border edge town city plaza club mall station capital market mart meet attract gather unify collect join focalize close on disjoin scatter divide arsenal center depot dump factory headquarters magazine plant range camp dock field garrison hangar harbor home port post settlement site starting point strip terminal antecedent assumption authority axiom backbone background backing base bedrock cause chief ingredient crux data dictum essential evidence explanation footing fundamental hard fact infrastructure justification keynote keystone law nexus postulate premise presumption presupposition principal element principle proof reason rudiment sanction security source substratum support theorem theory underpinning warrant affections circle conscience emotions feelings sentiments soul spirit sympathies Capitol Hill dome legislative hall political scene seat of government statehouse axial basic cardinal centric centroidal chief dominant equidistant focal foremost important intermediate key leading master median middle middlemost midmost nuclear omphalic outstanding overriding paramount pivotal predominant primary prime radical ruling salient significant umbilical armory basis bosom capitol central 2014 Sans sans san Antonio antonio forum meeting seminar huddle parley powwow talk gabfest appointment argument chat colloquy confabulation conferring congress consultation conversation convocation deliberation discussion groupthink interchange interview palaver round robin round table symposium think-in ventilation altercation analysis argumentation canvass conference consideration contention controversy debate dialogue discourse disputation dispute dissertation examination exchange excursus meet quarrel review scrutiny wrangling assembly colloquium conclave congregation convention council gathering get-together rally group discussion open discussion rap session workshop earful encounter eyeball-to-eyeball interlocution negotiation parlance spiel straight talk visit treble trine ternary third ternate trinal leash set of three ternion threesome trey triad triangle trilogy trinity triplet triplicate triptych triumvirate triune troika advance aggrandize aggravate amplify annex augment boost broaden build build up deepen develop dilate distend double enhance enlarge escalate exaggerate expand extend further heighten inflate intensify lengthen magnify mark up mount multiply pad progress proliferate prolong protract pullulate raise redouble reinforce rise sharpen slap on snowball spread step up strengthen supplement swarm swell tack on teem thicken triple wax widen pyramidal triangular trichotomic trichotomous trigonal trigonous trilateral trinary trinitarian tripartite three-bagger three-base shot trio increase three threefold three-base hit Triple S Triple Triple-S gloomy weak con balky anti good nay approval positive allergic to conflicting contrary detrimental disadvantageous down on down side have no use for inimical injurious inopportune negative opposed opposing opposite oppugning ornery reluctant repugnant stuffy unfortunate unfriendly unlucky unpropitious unwilling averse hesitant immovable indisposed inflexible intractable loath negativistic obstinate perverse stubborn unbending unmanageable unpredictable unruly confute contradict contravene controvert deny disaffirm disagree explode gainsay negate oppose repudiate abrogate annul atone for balance better cancel out counteract counterbalance counterpoise countervail fix improve invalidate make amends neutralize nullify outweigh redress repair set off belie buck call in question challenge confront counter cross dare differ disclaim disprove dispute fly in the face of have bone to pick impugn refuse to accept take on thumbs down traverse adverse antipathetic antipodal antipodean antithetical clashing contradictory contrariant contumacious converse diametric discordant dissentient dissident froward headstrong hostile inconsistent insubordinate nonconforming nonconformist paradoxical rebellious recalcitrant recusant refractory restive reverse wayward wrongheaded compensate Negative
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