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Inoffensive virus: can trigger celiac disease.

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Virus inofensivo: puede desencadenar la enfermedad celiaca.Un virus generalmente inofensivo puede desempeñar un papel en el desencadenamiento de la enfermedad celíaca, un nuevo estudio en ratones sugiere.Los investigadores encontraron que, entre los ratones que fueron manipulados genéticamente predispuestos a la enfermedad celíaca, los que fueron infectados con un virus llamado reovirus eran más propensos a tener una respuesta inmune frente al gluten que los ratones no infectados con un reovirus. Esta respuesta inmune es similar a lo que se ve en las personas con la enfermedad.A pesar de las infecciones humanas con los reovirus son comunes, los virus no causan síntomas en las personas. Pero el estudio también encontró que los pacientes con enfermedad celíaca tienen niveles más altos de anticuerpos contra el reovirus, en comparación con personas sin la condición.Los resultados sugieren que la infección por reovirus puede dejar una "huella permanente" en el sistema inmune que establece el cuerpo para desarrollar la enfermedad celíaca, según los investigadores.Dr. Bana Jabri, Director de Investigación en la Universidad de Chicago (Estados Unidos de América), Director de Investigación en la Universidad de Chicago Celíaca Centro de Enfermedades.Los investigadores también encontraron las personas con la enfermedad celíaca que tenía altos niveles de anticuerpos también había una mayor expresión de una generación que codifica una proteína llamada IRF1. En los estudios con ratones, los investigadores que IRF1 jugó un papel en el desarrollo de la intolerancia al gluten después de la infección con reovirus.


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