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Relapse After CML Treatment Discontinuation

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Naval Daver, MD; Kendra Sweet, MD; and Javier Pinilla-Ibarz, MD, PhD, discuss the treatment of patients with relapsed chronic myeloid leukemia and the data surrounding BCR-ABL TKI dose reduction in patients who maintain a major molecular remission for 1 year.


cancer oncology recidivism recurrence regression worsening backsliding fall lapse loss repetition retrogression return reversion setback fall from grace turn for the worse achievement success healing progress strengthening fall back degenerate retrogress worsen revert sicken sink fade regress fail suffer backslide recidivate be overcome be overtaken slide back slip back turn back get better win reach fight strengthen rise help develop heal grow increase improve attack access ailment bout breakdown convulsion disease failure fit illness paroxysm relapse seizure spasm spell stroke throe support retreat flight defense submission reprisal sustenance surrender shield shelter resistance protection aid health attacks backset disappointment discouragement downfall meltdown reversal reverse apostatize deviate sin slip decline abatement comedown cropper decay decrepitude degeneracy degeneration descent deterioration devolution diminution dissolution dive downgrade downturn drop dwindling ebb ebbing enfeeblement failing flop on the skids pratfall recession senility slump wane waning weakening strength growth development upgrade ascent betterment improvement accomplishment abate cheapen decrease depreciate deteriorate diminish disimprove disintegrate droop dwindle fall off flag go downhill go to pot go to the dogs hit the skids languish lose value lower pine recede retrograde rot sag settle shrink slide subside weaken go up say yes accept flourish build advance extend expand raise enhance ascend enlarge praise laud compliment vaxhole Relapse afterwards later subsequently back back of behind below ensuing hind hindmost in the rear next posterior postliminary rear subsequential succeeding thereafter before afterward after another time ensuingly eventually intra late latterly post hoc soon then thereon ultimately earlier previously beforehand afterward\u002Fafterwards a while later at a later time by and by in a while on the next day aback abaft aft astern backward final following in the wake of rearmost rearward tail beginning first future preceding front at the heels of at the rear of bringing up the rear eating the dust in the background in the wake later than off the pace trailing paid beyond above ahead apart from as well as at a distance away from besides beyond the bounds clear of farther free of good way off hyper in addition to in advance of long way off more remote moreover on the far side on the other side out of range out of reach outside over over and above over there past remote superior to without yonder consecutive chronological connected constant continuing continuous going on in order in turn increasing logical numerical one after another progressive running sequent sequential serial serialized seriate seriatim succedent successional successive understandable uninterrupted broken interrupted intermittent infrequent discontinuous afters vaxhole After CML vaxhole cml analysis cure hospitalization medication medicine operation prescription regimen remedy surgery therapy diet healing therapeutics disease injury harm hurt management employment practice strategy conduct approach method procedure proceeding reception habit custom manner way manipulation usage angle line execution mode modus operandi dealing processing action towards behavior towards aid advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benefit benevolence bounty care charity comfort compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement relief rescue reward salvation service shot in the arm subsidy sustenance treatment unkindness malevolence stop taking opposition handicap obstruction impediment blockage ill will silence disfavor stoppage hindrance damage penalty loss application administering administration applying creaming dosing rubbing applications TLC awareness big rush brace concern consciousness looking after notice observation recognition regard spotlight tender loving care neglect negligence disregard heedlessness ignorance carrying on channels charge control direction handling intendance leadership organization oversight plan policy posture red tape regulation rule running superintendence supervision tactics transaction wielding mismanagement disorganization antidote catholicon corrective counteractant counteragent countermeasure drug elixir elixir vitae fix healing agent help medicament medicant nostrum panacea pharmacon physic placebo proprietary quick fix recovery redress reparation restora-tive therapeutic problem vaxhole break cessation conclusion cutoff discontinuance discontinuity disruption ending gap halt interruption pause stay stoppage suspension beginning commencement continuation introduction persistence start abeyance discontinuation dormancy inactivity intermission latency postponement quiescence recess remission temporarily deferred waiting operation activity action revival renewal continuance abrogation annulment invalidation repudiation rescission retraction reversal withdrawal cut-off check termination delay adjournment bind cooling-off period cunctation dawdling demurral detention downtime filibuster hangup hindrance hold-up holding holding pattern impediment interval jam lag lingering logjam loitering moratorium obstruction problem procrastination prorogation putting off reprieve retardation retardment setback showstopper stall stop surcease tie-up wait rush expedition dispatch advance support promotion help speed hurry furtherance liberation assistance aid delays alternation cease close closing desistance desuetude disjunction finish separation stopping restarting opening initiation corruption disease malignancy sickness tumor canker carcinoma big C long illness health wholesomeness benignity Cancer vaxhole cancer oncology vaxhole
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