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Simulating How Proteins Self-Assemble, Or Fold

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Proteins control nearly all of life's functions, but how they self-assemble, or fold, is an unsolved problem in biology. Understanding how folding goes awry could ...

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distributed computing protein folding human biology computer cluster affect mimic replicate reproduce resemble act ape assume bluff borrow cheat concoct copy counterfeit crib deceive disguise dissemble equivocate exaggerate fabricate fake favor feature feign fence invent lie lift mirror misrepresent pirate play playact pose prevaricate steal act like do a take-off do like gloss over knock off make believe phony put on put on an act destroy face give idle meet receive reveal tell truth be on bring down the house burlesque characterize do a turn dramatize emote enact go on go over ham ham it up impersonate lay an egg make debut mime mug parody perform personate personify play act play gig play part play role portray pretend put it over rehearse represent simulate star stooge strut take part tread the boards halt give up direct stop fail refrain hesitate discontinue cease abstain prevent acted adopt aspire to contrive do a bit lay it on thick make out like put up a front sham take on affects imitate let alone leave not do reverse oppose differ doubt assumes according to what after what precedent by means of by virtue of what by what means by what method by whose help from what source through what agency through what medium to what degree whence whereby wherewith by which how through which wherein at which point in what respect where why cause motive mystery proof supertranslate H.O.W. 'how' How ascetic automatic autogenous automatous autonomic autonomous endogenous narcissistic narcistic subjective other myself character individuality person ego identity personality narcissism personal egocentrism psyche individual identical own selfhood substantive individualization oneself proprium being entity essence essentia essentiality marrow quintessence self soul spirit substance texture inanimate deadness abstract self-admiration self-pride selfdom egos circumstances coherence distinctiveness existence identification integrity ipseity name oneness particularity selfness singleness singularity status uniqueness opposition difference dissimilarity body child creature dude human being man material matter mortal number party personage singleton somebody something stuff type unit woman one group nothingness nothing individualism supertranslate amass bring together collect convene gather meet mobilize summon accumulate agglomerate bunch call capture convoke corral flock group huddle lump muster rally reunite unite bunch up call together come together gang up hang around hang out make the scene meet up round up scare up cancel disperse distribute divide scatter separate lose spread take apart manufacture join fit form set up construct compile produce erect fashion weld fabricate make contrive shape connect model mold piece together stop break wreck demolish disconnect raze ruin destroy accrue acquire add to aggregate amalgamate assemble cache clean up collocate concentrate cumulate draw together expand gain grow heap heap together hoard incorporate increase load up make a bundle make a killing mass pile pile up procure profit rack up roll up stack up stockpile store store up swell dissipate waste spend diminish shrink contract squander dwindle lessen decrease forfeit accumulated accumulates accumulating add up amount combine come mix number sum total break up detach aggregated supertranslate Assemble pleat bend circumvolution cockle convolution corrugation crease crimp crinkle flection flexure furrow gather gathering groove knife-edge lap lapel layer loop overlap plait plica plication ply pucker ridge ruck ruffle rumple shirring smocking tuck turn wrinkle plicature rimple rivel ruche line smoothness curl knit purse intertwine overlay replicate hem crisp double crumple plicate telescope corrugate dog-ear double over turn under succeed loose let out free unbend leave smooth separate divide open achieve loosen flatten straighten wrap involve entwine envelop enfold do up wrap up let go collapse crash give yield pauper break bust impoverish pauperize go under shut down be ruined become insolvent go bankrupt go bust go into Chapter 11 fix mend withhold accede accept acquiesce admit allow assent be game for cave in comply concede concur cooperate cry uncle endorse enter into fold give the go-ahead give the green light go along with grant let okay permit play ball roll over and play dead subscribe throw in the towel keep hold decline repel oppose disagree denounce demur condemn resist forbid prevent obstruct impede hinder repudiate dispute dissent disallow protest disapprove veto reject refuse deny bind adhere attach bandage border chain cinch clamp connect constrict cover dress edge encase enchain enfetter fetter finish furl glue hamper handcuff hitch hitch on hobble hook on hook up lace lash leash manacle moor muzzle paste peg down pin pin down pinion put together restrain restrict rope shackle stick strap swathe tack on tether tie tie up trammel trim truss unite yoke set free help untie unlace lose unfasten remove forget lay bare unbind detach assist aid liberate unhitch disjoin release center unlock disconnect unwrap uncover buckle bulge distort twist buckling burst fracture rupture exonerate busted Fold supertranslate appropriated assigned dispersed scattered shared allocated allotted dealt diffuse divided rationed given away handed out spread evenly broadcast catholic circulated diluted disseminated distributed expanded extended general prevalent propagated radiated separated strewn thin unconcentrated universal widespread short brief abridged abbreviated limited compressed compact condensed concentrated succinct restricted confined issued announced delivered expressed made public promulgated published spread released diffused disorderly disorganized messy rambling separate sowed sown spread out sprinkled assembled organized gathered united together connected abstracted apart asunder cut apart cut in two detached discrete disembodied disjointed distant disunited divergent divorced far between free in halves independent isolated loose marked parted put asunder removed set apart set asunder severed sovereign unattached unconnected associated subservient mixed joined combined disconnected distinct whole sympathetic attached figure out gauge cipher count enumerate figure measure rate reckon sum tally tot total tote add up cast up count heads count noses cut ice dope out keep tabs run down size up take account of tote up estimate guess subtract conjecture guesstimate surmise accounting auditing balancing the books bookkeeping calculating computing reckoning addition accretion accruing adding counting enlarging expanding increasing summation summing totaling toting deduction withdrawal subtraction shrinkage reduction loss lessening decrease additions computation calculation ciphering data processing estimating estimation figuring guesstimation making aggregating completing concluding consisting of constituting producing totalization Computing supertranslate Protein supertranslate protein bend crimp curl knit tuck cockle corrugate crisp crumple dog-ear double furrow gather groove hem intertwine lap overlap overlay plait pleat plicate pucker purse replicate ridge ruck ruffle telescope wrinkle double over ruche turn under straighten divide open separate smooth achieve flatten free leave let out loose loosen succeed unbend wrap involve entwine envelop enfold do up wrap up let go collapse crash give yield pauper break bust impoverish pauperize go under shut down be ruined become insolvent go bankrupt go bust go into Chapter 11 fix mend withhold efflorescence anthesis developing flowering folding rash redness Folding supertranslate animal mortal personal anthropoid biped hominid individual anthropological anthropomorphic bipedal civilized creatural ethnologic ethological fallible fleshly forgivable hominal hominine humanistic vulnerable immortal inhuman unmanly body life character child creature being soul personage wight plant nonentity inanimate abstract Cro-Magnon man Cro-Magnon Cro-Magnon race Homo sapiens Paleolithic man cave dweller caveman cavewoman human altruistic Robin Hood all heart benevolent big big-hearted bleeding heart charitable considerate generous good good scout humane humanitarian kind magnanimous openhanded philanthropic self-sacrificing selfish stingy uncharitable beast conscious thing entity human being living thing organism person thing deadness concept bodies party one thought immateriality spirit mind nothingness nothing fantasy bodily actual carnal corporal corporeal gross material natural normal organic physical sensual somatic substantial tangible unspiritual mental spiritual soulful humans supertranslate Humans Human anthropology biological science ecology environmental science medicine natural science zoology animal biology bioscience botany science of life study of living things life science physics chemistry pure science science of matter division dissection analysis investigation examination diagnosis inquiry cytology genetics etiology histology morphology embryology physiology connection anatomy biology supertranslate Biology CPU abacus analog brain calculator clone laptop mac mainframe microcomputer mini minicomputer adding machine artificial intelligence data processor digital electronic brain micro number cruncher personal computer thinking machine computer electronic calculator pocket calculator totaliser totalizer PDA computer hardware central processing unit computer unit disk drive floppy disk hard drive hardware magnetic disk microelectronics device modem output device supercomputer tape drive machine apparatus appliance automaton automobile contraption contrivance engine gadget implement instrument mechanism motor robot thingamabob tool vehicle widget end number account add add up aggregate amount come count heads count noses count off enumerate estimate figure in figure out include keep tabs numerate reckon run run down run into run to sum take account of tale tally tell tick off total tote tote up guess subtract numbers Computer supertranslate Computers array assemblage band batch bunch bundle chunk clump collection knot bevy blob body clutch covey crew gathering hunk lot pack party set individual one flock gather round up parcel package associate accumulate collect aggregate cumulate bunch up crowd around gang around let go divide spread separate dissemble scatter disperse agglomerate cluster lump mass pile agglomeration heap jumble load arrangement design display disposition exhibition formation host lineup multitude order parade pattern show supply throng arrays assembly accumulation aggregation association clambake coffee klatch company conclave confab conference convocation council crowd faction get-together group huddle meet meeting rally sit-in turnout division separation clique club corps coterie gang horde menagerie outfit society troop troupe supertranslate Cluster
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