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Single mutation in recessive gene increases risk of earlier onset Parkinson’s disease

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A collaboration of 32 researchers in seven countries, led by scientists at Mayo Clinic's campus in Florida, has found a genetic mutation they say confers a risk for ...


Mayo Clinic Health Care (Issue) Healthcare Science (Field Of Study) Parkinson's Disease Dr. Wolfdieter Springer PINK1 simple sole lone one loner odd only rare unique usual mixed wed solo free unwed abandoned batching it by itself/oneself companionless deserted desolate detached forlorn forsaken friendless hermit in solitary individual isolated lonely lonesome me and my shadow me myself and I on one's own onliest shag single solitary stag traveling light unaccompanied unaided unassisted unattached unattended unescorted unmarried widowed available celibate single person allocate allot appoint apportion appropriate assign authorize button down characterize charge choose commission connote constitute define delegate denote depute deputize describe dictate earmark elect evidence favor finger indicate individualize make mark mete name nominate opt peg pick pin down pinpoint prefer put down for reseve set apart set aside show slot stipulate tab tag tap a far cry from altered antithetic at odds at variance changed clashing colorful contradistinct contradistinctive contrary contrasting contrastive deviating differential discrepant disparate distant distinct distinctive divergent divers diverse incommensurable incomparable inconsistent like night and day mismatched mismated offbeat opposed other otherwise particular peculiar poles apart unalike unequal unrelated unsimilar variant various discrete dissimilar disunited especial separate separated several special specific unassociated characteristic cool diacritic diagnostic distinguishing excellent extraordinary far cry gnarly idiosyncratic original outstanding perfect proper singular superior typical uncommon unreal weird wicked alone bachelor designate different Single anomaly variation deviation evolution mutant novelty deviant change sameness inaction about-face accommodation adaptation adjustment amendment conversion correction difference diversification exchange fixing flip-flop metamorphosis mid-course correction modification mutation reformation remodeling reshaping revision shift switch switch-over transformation transmutation turn variance abnormality congenital anomaly congenital defect congenital malformation deformity disability addition advance break compression contraction development distortion diversity innovation modulation permutation reconstruction refinement reversal revolution surrogate tempering transition turnover variety vicissitude aberration alteration alterity crotch deflection departure detour digression disagreeing discrepancy disparity dissemblance dissimilarity dissimilitude distinction divagation divergency division fork otherness parting radiation ramification separation turning unlikeness varying flow fluctuation fluidity instability motion mutability unrest abortion chimera curiosity geek grotesque malformation miscreation misshape monster monstrosity oddity queer rarity sport weirdo birth defect divergence flux freak Mutation dormant latent dominant backward bashful coy demure diffident humble meek modest nongregarious not forward quiet rabbity recessive reclusive reserved restrained reticent self-effacing shrinking timid timorous unaffable unassertive unassuming unexpansive unsociable withdrawing withdrawn afraid apprehensive averse cautious chary circumspect conscious disinclined distrustful fearful hesitant indisposed introvert introverted loath loner nervous reluctant retiring shamefaced sheepish skittish suspicious unassured uneager uneffusive unresponsive unsocial unwilling wary aloof antagonistic brooding cold cool distant easy-going hostile inaccessible inhospitable laid-back secretive sensitive shy standoffish stuck-up unapproachable unbending uncommunicative uncongenial unforthcoming unneighborly uppity RNA chromosome gene genetic code heredity nucleic acid DNA Gene raise merger hike rise upsurge surge upturn gain boost upgrade access spread swell accrual step-up waxing loss drop widen build swarm pad wax teem annex mount narrow weaken hinder slow lessen cease raze recede hurt halt stop lower reduce shrink divide fall lose accretion addition augmentation enlargement extension increase increment accession accumulation build-up amassing amassment buildup accumulate amass build up collect enlarge flow gather grow accrue acquire add to agglomerate aggregate amalgamate assemble bring together cache clean up collocate compile concentrate cumulate draw together expand heap heap together hoard incorporate load up lump make a bundle make a killing mass pile pile up procure profit rack up roll up round up scare up stack up stockpile store store up unite agglomeration aggrandizement aggregation chunk collecting collection conglomeration gob growth hoarding hunk inflation intensification multiplication quantity stack stock trove upping prospect peril danger hazard exposure fortuity plunge fortune flyer jeopardy header accident stab venture openness wager gamble luck safety plan truth surety endanger imperil defy speculate brave confront encounter face chance adventure tackle meet menace dare beard take on guard dodge hide avoid save design bulkiness chanciness cumbersomeness hazardousness inconvenience perilousness risk troublesomeness uncomfortableness unhandiness unmanageability unwieldiness action ante betting down on long shot lot lottery odds odds on parlay play pledge pot raffle random shot shot shot in the dark speculation stake sweepstakes uncertainty buy in on dice game lay down lay odds play against play for play the ponies pony up put put money on set tempt fortune toss up trust be victim get hooked nibble volunteer bear challenge court face off fly in the face of go through outdare stand up to suffer support withstand advantage bad luck break cast casualty coincidence contingency destination destiny doom even chance fluke future good luck hap haphazard happening heads or tails hit in the cards kismet luck out lucky break misfortune occurrence outcome peradventure providence stroke of luck throw of the dice toss-up turn of the cards way the cookie crumbles wheel of fortune awkwardness bet bite Risk RISK prior later beforehand earlier early first foremost forward in front in the forefront in the lead leading previously advanced advancing ahead along ante antecedently at an advantage at the head before fore forwards in the foreground onward onwards precedent precedently preceding previous progressing to the fore as of now at present before now but now by now by that time by the time mentioned by then by this time even now formerly heretofore in the past just now now once then up to now anterior foregoing former past precursory preliminary ahead of time already in advance in anticipation precocious sooner ancient first-born more mature older senior advance antecedent elder outset origin rush access start charge onrush birth dawn onfall death end appearance approach arrival coming entrance occurrence onset visitation assailment assault blitz blitzkrieg encroachment injury invasion offense offensive onslaught push raid advance aggression incursion rape storm storming strike violation assailing barrage defilement dirty deed drive encounter foray initiative inroad intervention intrusion irruption mugging outbreak skirmish thrust volley action attack blitzkreig bloodshed bombing brush campaign carnage clash combat conflict contention crusade engagement fighting fray havoc hostility press ravage scrimmage significant contact sortie strife struggle war warfare alpha basis blastoff commencement creation dawning day one genesis inauguration inception induction infancy initiation installation introduction kickoff opener opening origination point of departure preface prelude presentation rise root rudiment source spring square one starting point takeoff threshold top advent battle beginning On set Onset malady stroke Cancer defect virus fever plague bug fit attack blight spell canker ache upset misery flu health boon adversity anguish calamity cross crux depression difficulty disease disorder distress grief hardship illness infirmity misfortune ordeal pain plight scourge sickness sorrow suffering torment trial tribulation trouble woe complaint condition dose indisposition syndrome access ailment bout breakdown convulsion failure paroxysm relapse seizure spasm throe bacillus germ infection microbe big C carcinoma corruption long illness malignancy tumor affection ill affliction cancer Disease DisEASE Mayo Clinic Mayo mayo hospital infirmary sick bay dispensary academics advisers body clinic college corps department employees institute instructors lecturers literati mentors organization pedagogues personnel professorate professors profs researchers scholars society staff tutors university workers emergency room health service hospice institution nursing home rest home sanatorium sanitarium surgery ward academy association asylum business company conservatory establishment fixture foundation guild orphanage school seminar seminary system think tank shelter faculty Clinic energy fitness verdure tone shape pink fettle stamina state vigor form bloom prime disease illness appearance aspect build constitution health kilter mint order phase repair status trim bliss dreamland ecstasy elation exaltation exhilaration exultation frenzy glee high spirits intoxication joy joyousness jubilation madness rapture relaxation transport good health robustness strength anatomy being condition figure frame object outline person phenomenon physique silhouette thing torso advantage big break blessing break fluke fortunateness godsend good luck happiness in the cards karma kismet luckiness lucky break occasion opportunity profit prosperity run of luck serendipity smile streak of luck stroke success triumph victory weal wealth win windfall agreement assurance covenant guarantee oath promise toast undertaking vow warrant word euphoria luck pledge Health HEALTH load strain fear worry charge woe dismay sorrow onus burden stress alarm sweat bother stew health aid relief joy delight calm benefit comfort help peace ease neglect effort wariness caution concern nicety interest exertion regard prudence trouble thought heed pains apathy laziness lethargy disregard ignorance omission oversight control trust keeping aegis ward watch tend protect attend sit mind foster mother nurse nurture wait on hate hurt enjoy love want cherish desire respect like prize take to amore ardor attachment care case closeness crush devotion emotion endearment feeling friendliness friendship good will hankering heart inclination itch kindness liking passion predilection propensity puppy love sentiment shine soft spot solicitude tenderness warmth weakness yen advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benevolence bounty charity compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement rescue reward salvation service shot in the arm subsidy sustenance treatment all-overs angst ants in pants apprehension botheration butterflies cold sweat creeps disquiet disquietude distress doubt downer drag dread fidgets flap foreboding fretfulness fuss goose bumps heebie-jeebies jitters jumps misery misgiving mistrust nail-biting needles nervousness panic pins and needles restlessness shakes shivers suffering suspense uncertainty unease uneasiness watchfulness willies worriment amenity assiduities civility compliment consideration deference gallantry mindfulness politeness authority countenance influence sponsorship supervision affection anxiety attention(s) auspices Care cares care? Health care Healthcare Health Care art system skill lore branch wisdom ignorance disorder ability accomplishment address aestheticism capacity civilization class courtesy cultivation delicacy dignity discrimination dress elegance elevation enlightenment erudition experience fashion finish gentility good taste grace improvement kindness learning manners nobility perception polish politeness practice proficiency refinement savoir-faire science tact training urbanity apprenticeship background book learning brainwashing breeding catechism coaching culture direction discipline drilling edification guidance inculcation indoctrination information learnedness literacy nurture pedagogy preparation propagandism proselytism reading rearing scholarship schooling study teaching tuition tutelage tutoring bookishness brains intellectuality knowledge letters pedantry savvy scholarliness studiousness advice ammo break chapter and verse clue confidence counsel cue data dirt dope dossier earful illumination info inside story instruction intelligence leak lowdown material message network notice notification orientation propaganda report scoop score tidings tip what's what whole story word accomplishments acquaintance apprehension attainments awareness cognition comprehension consciousness discernment doctrine dogma education expertise facts familiarity goods grasp insight judgment know-how light observation philosophy picture power principles recognition substance theory acquirements literature research SCIENCE! Science malady stroke Cancer defect virus fever plague bug fit attack blight spell canker ache upset misery flu health boon adversity anguish calamity cross crux depression difficulty disease disorder distress grief hardship illness infirmity misfortune ordeal pain plight scourge sickness sorrow suffering torment trial tribulation trouble woe complaint condition dose indisposition syndrome access ailment bout breakdown convulsion failure paroxysm relapse seizure spasm throe bacillus germ infection microbe big C carcinoma corruption long illness malignancy tumor affection ill affliction cancer Disease DisEASE D.R. Dr. fresh spring young autumnal verdant youthful vernal Springer springer
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