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The Pathogenesis of Plaque Rupture and ACS

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In a video originally posted on TheHeart.org | Medscape Cardiology, Amir Lerman, MD, and Charanjit (Chet) Rihal, MD, MBA, chair of the division of ...

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Mayo Clinic (Organization) Health Care (Issue) Healthcare Science (Field Of Study) Mayo Clinic TheHeart.org cardiology Amir Lerman Charanjit pathogenesis plaque vulnerable plaque acute coronary syndrome ACS structure vs amount in vivo autopsy plaque hemorrhage lumen shoulder rupture macrophages cardiovascular research inflammation comic sudden tense affecting breathtaking climactic dramaturgic dramaturgical effective electrifying emotional expressive farcical histrionic impressive melodramatic powerful sensational spectacular startling striking suspenseful the histrionical The plate medal badge slab disk brooch patch appliqué arabesque bauble braid color curlicue design dingbat doodad extravagance fandangle festoon filigree finery flounce flourish fretwork frill frippery furbelow fuss garbage garnish garniture gewgaws gilt gimcracks gingerbread inlay jazz lace ornament parquetry plaque ribbon scroll sequin spangle thing tinsel tooling trimming trinket wreath cairn ceremony column headstone inscription keepsake mausoleum memento monolith obelisk pillar record relic remembrance reminder shaft souvenir statue stele tablet token tombstone trophy decoration memorial Plaque schism breach burst tear rent crack cleft hernia peace rift division clash feud disunion break split divorce parting quarrel break-up bustup split-up unity closing union closure harmony erupt sever rive rend part hold open sew mend fix join sunder divide unite marry close agree breaking off coolness disaffection diverting estrangement indifference remoteness rupture separation setting against turning away variance withdrawal chasm chink cut eye fissure gap gash interstice opening orifice outlet passage perforation pinhole puncture slash slit slot space vent blast detonation eruption escape flat tire leak bomb detonate dynamite go off mushroom shatter aperture chip discontinuity hole alienation difference disagreement discord disharmony dissension disunity falling-out fracture parting of the ways secession severance strife blowout blow up also moreover additionally again along along with and as well as well as besides conjointly further furthermore in conjunction with in like manner including likewise more more than that on top of over and above plus still to boot together with too withal added aggrandized amassed another augmented bounteous deeper else enhanced exceeding expanded extended extra farther fresh heavier higher in addition increased innumerable larger major massed new numerous other spare supplementary too many wider And? AND heat service tension light current juice spark voltage C/A electromagneticism electron galvanism hot stuff ignition magneticism utilities central air central air conditioning climate control climatization air conditioning air cooling electricity ACS A.C.S. Mayo mayo hospital infirmary sick bay dispensary academics advisers body clinic college corps department employees institute instructors lecturers literati mentors organization pedagogues personnel professorate professors profs researchers scholars society staff tutors university workers emergency room health service hospice institution nursing home rest home sanatorium sanitarium surgery ward academy association asylum business company conservatory establishment fixture foundation guild orphanage school seminar seminary system think tank shelter faculty Clinic energy fitness verdure tone shape pink fettle stamina state vigor form bloom prime disease illness appearance aspect build constitution health kilter mint order phase repair status trim bliss dreamland ecstasy elation exaltation exhilaration exultation frenzy glee high spirits intoxication joy joyousness jubilation madness rapture relaxation transport good health robustness strength anatomy being condition figure frame object outline person phenomenon physique silhouette thing torso advantage big break blessing break fluke fortunateness godsend good luck happiness in the cards karma kismet luckiness lucky break occasion opportunity profit prosperity run of luck serendipity smile streak of luck stroke success triumph victory weal wealth win windfall agreement assurance covenant guarantee oath promise toast undertaking vow warrant word euphoria luck pledge Health HEALTH load strain fear worry charge woe dismay sorrow onus burden stress alarm sweat bother stew health aid relief joy delight calm benefit comfort help peace ease neglect effort wariness caution concern nicety interest exertion regard prudence trouble thought heed pains apathy laziness lethargy disregard ignorance omission oversight control trust keeping aegis ward watch tend protect attend sit mind foster mother nurse nurture wait on hate hurt enjoy love want cherish desire respect like prize take to amore ardor attachment care case closeness crush devotion emotion endearment feeling friendliness friendship good will hankering heart inclination itch kindness liking passion predilection propensity puppy love sentiment shine soft spot solicitude tenderness warmth weakness yen advancement advice advocacy alleviation allowance assist assistance attention backing backup benefaction benevolence bounty charity compensation cooperation deliverance encouragement endowment favor furtherance gift giving guidance hand handout leg up lift ministration ministry patronage promotion reinforcement rescue reward salvation service shot in the arm subsidy sustenance treatment all-overs angst ants in pants apprehension botheration butterflies cold sweat creeps disquiet disquietude distress doubt downer drag dread fidgets flap foreboding fretfulness fuss goose bumps heebie-jeebies jitters jumps misery misgiving mistrust nail-biting needles nervousness panic pins and needles restlessness shakes shivers suffering suspense uncertainty unease uneasiness watchfulness willies worriment amenity assiduities civility compliment consideration deference gallantry mindfulness politeness authority countenance influence sponsorship supervision affection anxiety attention(s) auspices Care cares care? Health care Healthcare Health Care art system skill lore branch wisdom ignorance disorder ability accomplishment address aestheticism capacity civilization class courtesy cultivation delicacy dignity discrimination dress elegance elevation enlightenment erudition experience fashion finish gentility good taste grace improvement kindness learning manners nobility perception polish politeness practice proficiency refinement savoir-faire science tact training urbanity apprenticeship background book learning brainwashing breeding catechism coaching culture direction discipline drilling edification guidance inculcation indoctrination information learnedness literacy nurture pedagogy preparation propagandism proselytism reading rearing scholarship schooling study teaching tuition tutelage tutoring bookishness brains intellectuality knowledge letters pedantry savvy scholarliness studiousness advice ammo break chapter and verse clue confidence counsel cue data dirt dope dossier earful illumination info inside story instruction intelligence leak lowdown material message network notice notification orientation propaganda report scoop score tidings tip what's what whole story word accomplishments acquaintance apprehension attainments awareness cognition comprehension consciousness discernment doctrine dogma education expertise facts familiarity goods grasp insight judgment know-how light observation philosophy picture power principles recognition substance theory acquirements literature research SCIENCE! Science Mayo Clinic sheik shah amir chieftain governor leader emir Amir Lerman charanjit plate medal badge slab disk brooch patch appliqué arabesque bauble braid color curlicue design dingbat doodad extravagance fandangle festoon filigree finery flounce flourish fretwork frill frippery furbelow fuss garbage garnish garniture gewgaws gilt gimcracks gingerbread inlay jazz lace ornament parquetry plaque ribbon scroll sequin spangle thing tinsel tooling trimming trinket wreath cairn ceremony column headstone inscription keepsake mausoleum memento monolith obelisk pillar record relic remembrance reminder shaft souvenir statue stele tablet token tombstone trophy decoration memorial Plaque exposed unsafe weak liable ready naked sucker tender guarded safe secure strong closed alarming bad breakneck chancy critical dangersome deadly delicate dynamite fatal formidable hairy heavy hot impending impregnable insecure jeopardous loaded malignant menacing mortal nasty on collision course parlous perilous portentous precarious pressing queasy risky serious serpentine shaky speculative terrible thorny threatening ticklish touch-and-go touchy treacherous ugly unhealthy unstable urgent viperous vulnerable wicked abased clinging counting on debased defenseless humbled immature indigent inferior lesser minor poor reliant relying on secondary subordinate tied to apron strings under under thumb unsustaining accessible in peril laid bare laid open left open menaced open prone sensitive subject susceptible threatened unguarded unprotected brittle dainty decrepit feeble fishy flimsy fracturable fragile frangible infirm insubstantial puny sad shatterable shattery sickly slender slight slim tenuous thin unsound unsubstantial wimpy wishy-washy wispy animal anthropoid anthropological anthropomorphic biped bipedal civilized creatural ethnologic ethological fallible fleshly forgivable hominal hominid hominine humanistic individual personal affectable affected feeling impressible influenceable ingenuous perceptive plastic receptive responsive sensible sensile sentient suggestible susceptive wax-like dangerous dependent frail human impressionable Vulnerable keen subtle intense sharp smart astute canny clever stupid honest blunt dull calm mild dense obtuse slow urgent severe sudden dire grave vital fierce kind peaked pointed spiked cuspate piked active acute alert athletic brisk buoyant bustling dexterous easy-moving energetic fleet frisky limber lithe lively mercurial prompt quick quick on the draw quick on the trigger quick-witted rapid ready spirited sportive spright sprightly spry stirring supple swift twinkle toes vigorous vivacious winged zippy Einstein advanced aware brainy brilliant clear-headed discerning eggheaded having smarts ingenious inventive knowing precocious whiz kid wide-awake accomplished bright expert genius gifted intellectual knowledgeable masterly penetrating profound talented whip clamant clamorous compelling critical crucial crying essential exigent imperative importunate instant pressing significant able adroit cagey careful cautious circumspect cunning discreet foxy frugal having fancy footwork hep intelligent judicious nimble-witted perspicacious prudent sagacious shrewd skillful slick slippery sly smooth street smart streetwise wary watchful wise with it worldly-wise climactical desperate paramount peak agile burning climactic cardiac arrest angina pectoris chest pains tachycardia cardiovascular disease congestive heart failure coronary coronary infarction coronary thrombosis myocardial infarction heart attack malady sign health ache bug complaint condition disease disorder dose flu illness indisposition infirmity syndrome affection ailment ill sickness upset association compound conglomerate ecosystem entanglement group network organization scheme structure synthesis system totality predicament problem temper weakness Cancer attack blight breakdown canker collapse contagion contamination convulsions debility decrepitude defect distemper endemic epidemic feebleness fever fit hemorrhage ill health infection inflammation misery pathosis plague seizure sickliness spell stroke temperature unhealthiness unsoundness virus visitation abuse affliction badness cruelty damage depravity destruction evil harm hurt injury insult malaise malice mischief pain suffering trial tribulation trouble unpleasantness wickedness woe wrong complex Syndrome network format system complex design fabric make texture anatomy build frame order disorganization house edifice cage pile bureaucracy chain of command hierarchy setup structure alignment array classification combination composition display disposition distribution form grouping lineup method ordering organization pattern pecking order ranging rank sequence association compound conglomerate ecosystem entanglement group scheme syndrome synthesis totality Gestalt contour figure outline shape arrangement cast configuration formation framework symmetry type architecture character construction content contents essence habit habitus nature physique temper temperament vitality apparatus conformation constitution load bulk chunk lot flock mint slew scads gob score pile mass mess heap peck hunk pack ton slat bags mucho sum cost body list tab net whole all one part import burden result value core sense matter thrust upshot nothing extend purport rival tally reach number effect touch become total grow match mean come to leave fail accumulation agglomerate agglomeration amount assemblage combination conglomerate conglomeration gross lump mixture quantity the works totality whole ball of wax whole enchilada whole schmear whole shooting match accumulate add up amass assemble collect combine come mix aggregation array assortment bunch bundle clump cluster clutch collection crowd group parcel set shipment volume advance declaration feeler hit invitation offer pass price proffer proposal proposition request submission suggestion summons tender aggregate amplitude bigness dimensions extent immensity magnitude massiveness quantum substance weight bad news bite damage expenditure expense nick outlay payment price tag rate squeeze tariff tick batch bid charge Vivo postmortem dissection necropsy anatomization anatomy autopsy dismemberment examination operation vivisection analysis apportionment bisection breaking breaking down breaking up carving contrasting cutting up demarcation departmentalizing detaching detachment diagnosis disjuncture disparting disseverance dissolution distinguishing distribution disunion disuniting dividing divorce parceling parting partition reduction rending rupture segmentation selection separating severance splitting up subdivision biopsy exam inquiry observation physical postoperative probe test coroner's report post critique post-mortem examination review check checkup inspection perusal scrutiny study view division post mortem going-over Autopsy ooze drain seep gush pour exude hemorrhage leech open vein phlebotomize run shed spurt trickle weep Cancer ache affection attack blight breakdown bug canker collapse complaint condition contagion contamination convulsions debility decrepitude defect disorder distemper endemic epidemic feebleness fever fit flu ill health illness indisposition infection infirmity inflammation malady misery pathosis plague seizure sickliness sickness spell stroke syndrome temperature unhealthiness unsoundness upset virus visitation abrasion abuse affliction affront agony bad bite blemish boo-boo bruise burn chop cramp cut damage deformation detriment discomfiture disservice distress evil fracture gash grievance ill impairment indignity injustice insult laceration lesion libel loss mischief mutilation nick ouch outrage pang ruin scar scratch shock slander sore sprain stab sting suffering swelling trauma twinge wound wrong acerbity acrimony agitation animosity apoplexy asperity bitterness blowup bluster choler convulsion dander eruption exasperation excitement explosion ferment ferocity fireworks frenzy furor fury gall heat huff hysterics indignation ire irritation madness mania obsession outburst paroxysm passion rampage raving resentment spasm spleen squall storm tantrum temper umbrage uproar vehemence violence wingding wrath anger conniption flare-up temper tantrum wax bleed disease injury rage lumen assume accept carry bear take on deny nudge shove press elbow thrust hustle refuse pull cherish entertain exhibit harbor have hold hold up maintain possess shoulder sustain uphold weigh upon attend back buck chaperon companion conduct consort convey deliver escort fetch gather guide gun heel import lead lug pack pick up piggyback ride schlepp take take along tote transfer transport truck usher backpack bring cart channel convoy displace ferry freight funnel give haul heft hoist lift move pipe portage relay relocate remove shift traject transmit transplant waft dispatch forward grant hump send siphon support bend bulldoze bump crowd hook jostle knock rough and tumble be sold for bring back bring to call for draw forth earn elicit get give rise to go for make obtain produce realize retrieve sell sell for yield Shoulder Shoulders schism breach burst tear rent crack cleft hernia peace rift division clash feud disunion break split divorce parting quarrel break-up bustup split-up unity closing union closure harmony erupt sever rive rend part hold open sew mend fix join sunder divide unite marry close agree breaking off coolness disaffection diverting estrangement indifference remoteness rupture separation setting against turning away variance withdrawal chasm chink cut eye fissure gap gash interstice opening orifice outlet passage perforation pinhole puncture slash slit slot space vent blast detonation eruption escape flat tire leak bomb detonate dynamite go off mushroom shatter aperture chip discontinuity hole alienation difference disagreement discord disharmony dissension disunity falling-out fracture parting of the ways secession severance strife blowout blow up probe inquiry analysis inquest scrutiny quest probing delving R and D legwork ignorance explore consult analyze inquire look up do tests ignore audit checkup control investigation poll rein research review test burrow dig dredge examine excavate ferret out go into gouge out investigate jump into leave no stone unturned look into prospect ransack really get into rummage scoop out search seek shovel sift spade trowel turn inside out unearth bring to light come across come up with delve dig down expose extricate find retrieve root search high and low shake down turn upside down uncover examination exploration inquisition inspection interrogation query questioning study assay battery blue book breakdown canvass catechism checking cross-examination diagnosis dissection exam experiment final grilling make-up observation once-over oral perlustration perusal questionnaire quiz raid reconnaissance scan survey the eye third degree trial tryout view written appraise case check check out chew over consider criticize delve into dig into eye finger frisk go over go through gun inspect look over look see parse pat down peruse pick at ponder pore over prove read reconnoiter scope screen scrutinate scrutinize search into size up sweep take stock of try turn over vet weigh winnow enquiry Research pain rash sore condition deepening exacerbation exaggeration heightening increase inflaming inflammation intensification magnification sharpening strengthening worsening Cancer ache affection attack blight breakdown bug canker collapse complaint condition contagion contamination convulsions debility decrepitude defect disorder distemper endemic epidemic feebleness fever fit flu hemorrhage ill health illness indisposition infection infirmity malady misery pathosis plague seizure sickliness sickness spell stroke syndrome temperature unhealthiness unsoundness upset virus visitation affliction ailment disability abscess acne beauty spot blackhead blemish blister boil bump carbuncle caruncle excrescence furuncle hickey lump papula papule pustule spot whitehead zit bruise bulge bunion contusion corn dilation distention enlargement hump injury knob knurl node nodule pimple pock protuberance puff puffiness ridge tumescence tumor wale wart weal welt excitability hypersensitivity irritability oversensitiveness oversensitivity rawness soreness susceptibility susceptibleness tenderness tenseness aggravation disease swelling irritation
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