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The Science of Depression

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Science AsapSCIENCE Depression Depressed Sad Lonely Sadness Bipolar Robin Williams Mental Health Chemical Imbalance Neurotransmitter Suicide Brain Cell Brain Hippocampus Nervous System Emotion Stress Anxiety Disorder Neurons Mood Serotonin Drugs Social Genetics Gene Life Cause Trauma Disease Biology Biological Whiteboard Cartoon comic sudden tense affecting breathtaking climactic dramaturgic dramaturgical effective electrifying emotional expressive farcical histrionic impressive melodramatic powerful sensational spectacular startling striking suspenseful the histrionical The art system skill lore branch wisdom ignorance disorder ability accomplishment address aestheticism capacity civilization class courtesy cultivation delicacy dignity discrimination dress elegance elevation enlightenment erudition experience fashion finish gentility good taste grace improvement kindness learning manners nobility perception polish politeness practice proficiency refinement savoir-faire science tact training urbanity apprenticeship background book learning brainwashing breeding catechism coaching culture direction discipline drilling edification guidance inculcation indoctrination information learnedness literacy nurture pedagogy preparation propagandism proselytism reading rearing scholarship schooling study teaching tuition tutelage tutoring bookishness brains intellectuality knowledge letters pedantry savvy scholarliness studiousness advice ammo break chapter and verse clue confidence counsel cue data dirt dope dossier earful illumination info inside story instruction intelligence leak lowdown material message network notice notification orientation propaganda report scoop score tidings tip what's what whole story word accomplishments acquaintance apprehension attainments awareness cognition comprehension consciousness discernment doctrine dogma education expertise facts familiarity goods grasp insight judgment know-how light observation philosophy picture power principles recognition substance theory acquirements literature research Science SCIENCE! xkcd bitches bitck works red rocket. sceince scientist scientific method understanding universe astronomy astrology mad scientists evil geniuses frankenstein don&39;tgonearthe castle distress dole trouble worry bummer dullness sorrow qualm gloom dumps sadness dolor misery ennui blahs vapors lowness joy hope surge bulge peace cheer drop sag crisis bust panic crash slump slide calm success rise bowl dent pit scoop void sink hole dip basin solid adversity anguish calamity cross crux depression difficulty disease disorder grief hardship illness infirmity misfortune ordeal pain plague plight scourge sickness suffering torment trial tribulation woe Weltschmerz agony apprehension blues dread mid-life crisis misgiving nervousness uneasiness bay concavity ewer gulf hollow lagoon pan pool pot sinkage sinkhole tub valley vessel washbasin washbowl watershed armpit atrium bursa caries chamber crater decay gap pocket sinus socket vacuity declivity decrease descent downslide downswing downtrend downturn drop-off fall-off hill incline lapse loss lowering pitch slip slope abatement compression condensation constriction contraction cutback decline declining decrescence diminution discount dwindling ebb falling off reduction shrinkage striction subsidence waning affliction angst cavity Depression morose unhappy sad blue down low weeping bad crummy fed up glum grim moody ripped hurting dragged in pain torn up glad lucky happy gay above rich sunken hollow convex raised poor weakened needy ghost impaired deprived run-down shanty skid row devalued ghetto strong afflicted depressed disturbed grieving harmed hurt injured oppressed pained peeved persecuted saddened woeful wronged apologetic conscience-stricken contrite crestfallen dejected disconsolate downcast downhearted guilty regretful remorseful upset woebegone despondent dismal dispirited down in the dumps gloomy melancholy beaten browbeaten crippled crushed defeated demoralized discouraged disheartened heartsick humbled overpowered subdued tamed vanquished austere black bleak comfortless dark dejecting desolate dispiriting dolorous drab draggy drearisome dreary dull forlorn funereal in the dumps jarring joyless miserable mopey mournful oppressive somber sorrowful sullen tenebrific uncomfortable wintry ass in a sling cast down chapfallen in a funk inconsolable singing the blues taken down aggrieved broken cheerless Depressed bitter somber dismal sorry blue down gloomy glum low morbid morose glad lucky happy nice good great dark moving bad tragic dreary grave shabby joyful bright light right abominable amiss atrocious awful bad news beastly blah bottom out bummer careless cheap cheesy crappy cruddy crummy defective deficient diddly dissatisfactory downer dreadful erroneous fallacious faulty garbage godawful grody gross grungy icky imperfect inadequate incorrect inferior junky lousy not good off poor raunchy rough sad slipshod stinking substandard synthetic the pits unacceptable unsatisfactory apologetic conscience-stricken contrite crestfallen dejected depressed disconsolate downcast downhearted guilty regretful remorseful upset woebegone bleak depressing depressive dispiriting distressing doleful foreboding funereal horrible lugubrious mournful ominous oppressive sinister sombre threatening black cheerless comfortless discouraging disheartening drear grim hard harsh hopeless joyless lonely melancholy unpromising claustrophobia climbing the walls distress neurosis restlessness temporary insanity winter blues austere dejecting desolate despondent dolorous drab draggy drearisome dull forlorn in the dumps jarring miserable mopey sorrowful sullen tenebrific uncomfortable wintry woeful cabin fever Sad SAD S.A.D. S a D suck dick penis cock drinks pub night tnd wnd thnd fnd mnd sunday weekend valentines day bloody valentine depression heart break empty alone apart down left lone outcast single loved close solitary desolate remote isolated quiet deserted obscure private removed retired secluded secret abandoned batching it by itself/oneself companionless detached forlorn forsaken friendless hermit in solitary individual lonely lonesome me and my shadow me myself and I on one's own onliest only shag sole solo stag traveling light unaccompanied unaided unassisted unattached unattended unescorted unmarried widowed black cheerless comfortless dark discouraging disheartening dismal drear dreary funereal gloomy grim hard harsh hopeless joyless melancholy mournful oppressive sad somber unpromising arid bare infertile sterile uninhabited unproductive untilled waste wild barren bereft cast off derelict godforsaken left in the lurch left stranded lorn neglected relinquished uncouth vacant bleak desert destroyed ruined unfrequented unoccupied acheronian blue dejected disconsolate dolorous downcast hurting in a blue funk inconsolable miserable tragic wretched Lonely sorrow grief misery anguish letdown bummer woe downer funk dolor mopes blahs dismals joy cheer dejection despondency doldrums dumps gloom gloominess glumness heavy heart low spirits melancholy moodiness mournfulness sadness the dismals the mopes unhappiness abasement abjection abjectness bleakness blue funk cheerlessness desolation desperation disconsolation discouragement dispiritedness distress dole dolefulness downheartedness dreariness dullness ennui heaviness of heart heavyheartedness hopelessness lowness lugubriosity melancholia mortification qualm the blues trouble vapors woefulness worry despair loneliness mourning wretchedness cold feet depression disappointment discomfiture dismay loss of confidence pessimism ache affliction anxiety bad news blues care concern cross discomfort disquietude embarrassment headache heartache heartbreak irritation malaise ordeal pang perplexity shame stew suffering throe torment torture trial tribulation twinge unconsolability vexation visitation worriment agony passion ruth Sadness vibrating mercurial spasmodic two-faced steady fixed bipolar Bipolar bi-polar Robin Williams ROBIN WILLIAMS robin williams robin Robin William william psychic brainy deep heavy inner unreal phrenic sane body lunatic mad maniac nuts fruity loco nutsy abnormal atypical bizarre deviant different flaky mental nonstandard odd off-base off-color out of line peculiar psycho strange unusual weird berserk certifiable crazy demented deranged frenzied hysterical manic out of one's mind psychopathic raving ape barmy bats in the belfry batty bonkers cracked crazed cuckoo daft delirious dingy dippy erratic flipped flipped out freaked out idiotic insane kooky mad as a March hare mad as a hatter maniacal moonstruck nutty nutty as fruitcake of unsound mind out of one's tree out to lunch potty round the bend schizo screw loose screwball screwy silly touched unbalanced unglued unhinged unzipped wacky absurd asinine bedlamite crackers daffy dopey foolish fried giddy half-baked in the ozone inane off the wall out of one's gourd ridiculous simple unsound whacko witless abstract chimerical dreamlike extravagant fanciful fictitious high-flown hypothetical imaginary in the clouds intellectual ivory-tower mercurial notional out-of-reach quixotic theoretical transcendent transcendental unattainable unearthly utopian visionary derailed fatuous impractical irrational irresponsible loony off one's rocker paranoid preposterous psychotic rabid raging schizophrenic senseless unsettled wild aberrant ideal Mental M.E.N.T.A.L energy fitness verdure tone shape pink fettle stamina state vigor form bloom prime disease illness appearance aspect build constitution health kilter mint order phase repair status trim bliss dreamland ecstasy elation exaltation exhilaration exultation frenzy glee high spirits intoxication joy joyousness jubilation madness rapture relaxation transport good health robustness strength anatomy being condition figure frame object outline person phenomenon physique silhouette thing torso advantage big break blessing break fluke fortunateness godsend good luck happiness in the cards karma kismet luckiness lucky break occasion opportunity profit prosperity run of luck serendipity smile streak of luck stroke success triumph victory weal wealth win windfall agreement assurance covenant guarantee oath promise toast undertaking vow warrant word euphoria luck pledge Health HEALTH actinic ammo armament ball bomb buckshot bullet cannonball cartridge charge chemical confetti explosive fuse grenade gunpowder iron rations materiel missile munition napalm powder rocket round shell shot shrapnel torpedo cast ersatz false manufactured phony pseudo substitute synthetic unnatural alcohol formaldehyde salt saltpeter vinegar ammunition plastic preservative Chemical [chemical] inequality asymmetry unevenness alterity discrepancy disproportion dissemblance dissimilarity dissimilitude distinction divergence divergency diverseness gap imbalance imparity incongruity otherness unlikeness variation aberration absurdity alienation asininity dementia derangement distraction fatuity folly foolhardiness foolishness idiocy imbecility inanity ineptitude insanity mania psychopathy psychosis senselessness silliness stupidity fretfulness hysteria irritation nervousness neurasthenia sleeplessness strain stress tenseness tension crookedness dissymmetry lack of balance lopsidedness skewness disparity inequity unequalness lunacy mismatch nerves disproportionateness hara-kiri seppuku mélange suicide Brain Cells brain cells pundit doctor sage genius dumbo dumdum body head wit advance aggress ambush assail assault bash bat bean beat beset besiege biff blast blister boff bombard boot bop brain bust charge chop down clip clock club combat cook harm hit hurt infiltrate invade jump kick knock block off knock cold knock for a loop larrup lay siege to light into molest mug overwhelm pounce upon punch raid rush set upon slog soak stab storm strike take the offensive turn on wallop whop CPU abacus adding machine analog artificial intelligence calculator clone data processor digital electronic brain laptop mac mainframe micro microcomputer mini minicomputer number cruncher personal computer thinking machine architect author begetter deity designer founder framer generator initiator maker originator prime mover producer sire acuity acumen astuteness discernment intellect intelligence keenness penetration profoundness profundity sagacity sense sharpness weightiness bluestocking bookworm geek highbrow know-it-all longhair rocket scientist scholar thinker Einstein ability accomplishment acuteness adept aptitude aptness bent brilliance capability capacity creativity endowment expert faculty flair grasp imagination inclination ingenuity inspiration inventiveness knack mature originality percipience perspicacity power precocity prodigy propensity prowess reach superability talent turn understanding virtuoso wisdom attack computer creator depth egghead Brains brain(s) brains germ egg unit embryo spore cage crib booth crypt nook pen coop vault hole hold keep stall den tower alcove antechamber apartment bedchamber bedroom box case cavity cell chest container cubicle enclosure flat hall hollow lodging pocket room socket abbey chapter house convent friary hermitage house lamasery monastery nunnery order priorate priory religious community retreat sanctuary area bay berth carrel carriage category chamber corner cubbyhole department division locker niche part piece pigeonhole place portion slot catacomb cave cavern compartment grave grotto mausoleum sepulcher tomb undercroft desk office work area oubliette torture chamber cloister dungeon Cell hippocampus Hippocampus nerves nerve system neurology sense organs sensorium shaky afraid jumpy weak uneasy tense timid shy edgy fussy fitful nervy taut upset wired brave firm sure calm happy bold cool abashed aghast alarmed anxious apprehensive aroused blanched cowardly cowed daunted discouraged disheartened dismayed distressed disturbed faint-hearted frightened frozen have cold feet horrified in awe intimidated nervous panic-stricken perplexed perturbed petrified rattled run scared scared scared stiff scared to death shocked spooked startled stunned suspicious terrified terror-stricken timorous trembling worried antsy basket case bugged butterflies careful choked clutched concerned disquieted dreading fearful fidgety fretful hacked hyper in a state in a tizzy in suspense jittery overwrought restless shaking shivery shook up shot to pieces solicitous strung out sweating bullets troubled unglued unquiet uptight watchful worried sick wreck alarming astonishing awe-inspiring awful beautiful breathtaking daunting dreadful exalted fearsome formidable frantic frightening grand hairy horrible horrifying imposing impressive intimidating magnificent majestic mean mind-blowing moving overwhelming real gone shocking something else striking stunning stupefying terrible terrifying wonderful wondrous zero cool backward blushful blushing chary confused constrained coy demure diffident embarrassed humble modest overmodest recoiling reserved reticent retiring self-conscious self-effacing shamefaced sheepish shrinking silent unassertive verecund curt irritable prim short stiff stilted base caitiff chicken-hearted cowering cowhearted craven dastardly fainthearted gutless having the willies lacking courage lily-livered no guts panicky paper tiger pigeonhearted pusillanimous recreant running scared soft spineless weak-kneed worthless yellow yellow-bellied awesome bashful brittle scheme rule theory integral setup ideology complex totality entity sum red tape cog part practice process strategy policy tactics pattern artifice custom fashion manner way routine usage wise mode modus reality alignment array classification combination composition design display disposition distribution form grouping lineup method ordering organization pecking order ranging rank sequence structure system canon charter codex constitution convention digest discipline ethics etiquette manners maxim regulation association compound conglomerate ecosystem entanglement group network syndrome synthesis balloters body of voters body politic citizenry city county district electorate electors faction nation people precinct state voters voting area ward architecture arrangement assembly build cast conception contour cut development edifice elevation erecting erection fabric fabricating fabrication figuration figure format formation foundation improvisation invention makeup making manufacture mold origination outline plan planning prefab prefabrication putting up raising rearing roadwork shape systematization turn type advancement chain channels consecution continuity flow furtherance line march movement order polity procedure program progression row sequel series string succession unfolding code constituency construction course System love shame anger fervor pride warmth joy sorrow grief desire rage drive affect ardor tremor thrill zeal vibes hate hatred woe calm apathy quiet peace cheer amore attachment care case closeness concern crush devotion emotion endearment feeling friendliness friendship good will hankering heart inclination itch kindness liking passion predilection propensity puppy love regard sentiment shine soft spot solicitude tenderness weakness yen climax comedy crisis dramatics excitement farce histrionics melodrama scene spectacle tension theatrics tragedy activity ardency avidity conviction craze dash eagerness earnestness ecstasy energy exhilaration fad fanaticism fever fieriness fire flame flare frenzy fury gaiety glow heat hilarity hobby impetuosity intensity interest joyfulness keenness life mania mirth nerve oomph orgasm pep rapture red heat relish snap spirit transport vehemence verve vim vivacity zealousness zest élan action ado adventure agitation animation bother buzz commotion confusion discomposure disturbance dither drama elation excitation ferment flurry furor fuss hubbub hullabaloo hurry hysteria impulse instigation intoxication kicks motivation motive movement perturbation provocation stimulation stimulus stir titillation to-do trepidation tumult turmoil urge wildness affection appreciation behavior capacity compassion cultivation culture delicacy discernment discrimination empathy faculty fondness imagination impression intelligence intuition judgment palpability pathos pity reaction refinement sensibility sensitivity sentimentality sharpness sympathy tangibility taste understanding brouhaha bustle fireworks racket ruckus rumpus enthusiasm hoopla Emotions e-motions depression happiness feelings indecisiveness rationality pragmatism discipline emoticon emote stupid twat idiot xtc emotional ecstacy love drug einsteins blue dolphins mitsubishi love hearts red crosses weight force accent beat import ignorance relaxation tension anxiety hardship crunch agony strain heat trauma burden hassle fear worry spring stretch disquiet traction passion ferment draw flutter pull clutch alarm mistrust trial dread urgency tautness tensity health relief calm ease peace help trust repeat spot feature belabor harp on play up rub in reduce relax distend overdo afflict tense fret aid significance stress accentuate draw attention to emphasize highlight intensify underline underscore bring attention to call attention to give prominence to point up spotlight apprehension cold feet consternation dismay distress fright horror nervousness panic scare terror trepidation unease uneasiness advance affirm allege argue asservate attest aver avouch avow butt in cite claim contend defend horn in justify mouth off pop off predicate press proclaim profess pronounce protest put forward say shoot off one's mouth shoot one's wad stand up for state swear uphold vindicate warrant full force impact pressure shock thrust violence assert brunt Stress disquiet unease mistrust angst jitters doubt dread misery suspense trouble panic concern distress fuss downer flap drag care sweat shivers shakes jumps fidgets needles willies creeps calm joy ease peace trust belief faith anxiety apprehension cold feet consternation dismay fright horror nervousness scare strain stress tension terror trepidation uneasiness ado aggravation annoyance bellyache botheration bustle difficulty exasperation flurry headache irritant irritation molestation nudge nuisance pain pain in the neck perplexity pest plague pother pressure problem to-do trial vexation worriment worry Herculean task accountability affliction albatross ball and chain blame charge clog deadweight duty encumbrance excess baggage grievance hardship hindrance load millstone misfortune mishap obstruction onus punishment responsibility sorrow task tax thorn in one's side weary load work alarm anguish bother burden chagrin discomposure disturbance fear foreboding fretfulness handicap impediment incubus misgiving oppression solicitude stew tribulation unhappiness woe backing out chicken heart faint heart reservations second thoughts timidity weak knees white feather yellow streak a thing about something exaggerated reaction fixation fixed idea hang-up idée fixe insanity mania neurosis obsession phobia preoccupation repression complex Anxiety huddle mess disarray muddle anarchy snarl jumble shambles ataxia health order method system rule chaos unrest trouble ruckus mayhem static flap misrule discord fight hubbub strike clamor bustle turmoil tizzy fuss riot brawl fracas tumult uproar rumpus dither quarrel rioting mob rule calm quiet peace malady disease ailment upset tumble embroil confuse clutter shuffle derange disrupt rummage disturb rumple scatter mess up muss up neaten tidy soothe adversity anguish calamity cross crux depression difficulty disorder distress grief hardship illness infirmity misery misfortune ordeal pain plague plight scourge sickness sorrow suffering torment trial tribulation woe ache bug complaint condition dose flu indisposition syndrome confusion disorganization disregard hostility nihilism nongovernment rebellion reign of terror revolution affray altercation argument battle battle royal bickering broil clash dispute donnybrook duke out feud fray free-for-all hassle melee rhubarb row rumble scrap scuffle squabble wrangle bedlam entropy holy mess lawlessness mix-up mobocracy pandemonium rat's nest topsy-turviness unruliness derangement hodgepodge litter medley melange mélange scramble untidiness affliction Disorder neuron neurons color mind scene humor spirit desire wish air aura whim bent feel fancy strain tenor blues cue vein vagary timbre soul dumps temper hate joy address affectation ambience appearance atmosphere bearing comportment demeanor deportment effect feeling flavor impression look manner mannerism mien mood pose presence property quality semblance tone background character climate environment local color medium place sense space surroundings taste angle approach belief bias disposition frame of mind headset inclination leaning like it is mental state mindset mindtrip notion opinion perspective philosophy point of view position posture predilection prejudice proclivity reaction routine say so sensibility sentiment set slant stance stand standing standpoint temperament twist view where one is at aspect emanation scent suggestion bee caper changeableness contrariety crotchet fad fickleness fitfulness fool notion freak gag impulse inconsistency inconstancy jerk kink peculiarity perversity put on quirk rib thought whimsy attribute badge caliber cast complex complexion constitution crasis emotions estimation ethos frame genius grain habit kind makeup mettle morale mystique nature personality record reputation repute shape singularity sort specialty streak style trait turn type attitude caprice Mood Serotonin poison remedy cure pill tonic potion dope opiate essence physic disease hit numb relax fix dose treat blunt ignore aid alleviation antidote assistance catholicon corrective counteractant counteragent countermeasure drug elixir elixir vitae healing healing agent help medicament medicant medication medicine nostrum panacea pharmacon placebo proprietary quick fix recovery redress reparation restora-tive therapeutic treatment balm cologne effusion extract fragrance juice liquor perfume scent spirits tincture black hash black oil cannabis ganja grass hash hemp marijuana narcotic pot big H candy crap diacetylmorphine doojee flea powder hard stuff horse junk mojo opium scag white stuff anesthetize bring under control captivate charm dull the will entrance fascinate hold under a spell induce lull to sleep magnetize make drowsy make sleepy mesmerize narcotize put to sleep soothe stupefy subject tosuggestion California sunshine Owsley Owsley's acid acid blotter acid blue heaven cubes dots electric Kool-aid hallucinogen instant Zen mellow yellows microdots purple haze strawberry fields sunshine tabs yellow sunshine hashish heroin hypnotize LSD Drugs drugs civil cordial group general common nice amusing polite popular aloof unusual cool rare private communal gathering harvest party social work party accepted coincident collective communal communistic community commutual congruous conjoint conjunct constant corporate correspondent customary generic in common intermutual joint like mutual prevailing prevalent public reciprocal shared socialistic united universal usual well-known widespread affable amicable buddy buddy clubby complacent congenial conversable convivial cozy cozy with familiar genial good-natured gregarious intimate mellow neighborly outgoing pally palsy sociable tight tight with adapted agreeable amical companionable compatible complaisant consistent consonant cooperative delightful favorable fit good-humored gracious happy harmonious jovial kindly kindred like-minded pleasant pleasing regular fellow right neighborly suitable sympathetic well-suited affectionate buddy-buddy cheerful earnest glowing heart-to-heart heartfelt hearty invigorating palsy-walsy red-carpet responsive sincere tender warm warmhearted welcoming wholehearted ball brawl disco formal hoedown hop jump masquerade mingle prom promenade shindig sock hop bee dance Social socials division medicine analysis diagnosis inquiry biology cytology etiology zoology histology connection ecology anatomy phytology pomology taxonomy morphology pathology physiology dendrology floristics strain line stock stemma stirps ancestry inheritance eugenics genesiology acquirement dissection embryology examination genetics investigation horticulture natural history paleo-botany phytogeography study of flora study of vegetation blood line derivation descent extraction generation heredity history lineage parentage pedigree progeniture congenital traits constitution genetic make-up inborn character botany genealogy Genetics genetic science fraud pseudoscience dna chemical imbalance RNA chromosome gene genetic code heredity nucleic acid DNA Gene genes heart soul being dash zing brio vigor zest oomph verve élan apathy death time orbit epoch era span cycle days end body living woman person growth man essence entity human flesh breath animal mortal plant career story journal memoir bio development lifestyle behavior world personality knowledge enjoyment conduct attainment suffering journey realization happiness way of life woe activity agility alacrity alertness animation bag ballgame big idea bit business bustle commotion deal energy enterprise flurry force functioning game going happening haste hoopla hopper in the works industry life liveliness motion movement occupation operation plan power process proposition racket reaction response rush scene spirit stir stunt trip turmoil vim vitality vivacity action activeness exercise exertion hustle labor adolescence adulthood boyhood childhood dotage elderliness girlhood infancy lifetime majority maturity middle age milestone old age senility seniority wear and tear youth aeon blue moon century date day duration generation interim interval millennium ardor bounce briskness buoyancy dynamism ebullience elation enthusiasm esprit excitement exhilaration fervor gaiety high spirits passion pep sparkle sprightliness vibrancy zap zeal zip adventures biography confession diary experience letter letters life story personal history reminiscences self-portrayal age autobiography Life origin matter motive source root spring ground end author agency doer object basis aim leaven maker result outcome product effect finish neglect fruit issue faith goal ideal plan creed begin create induce produce provoke generate make hatch breed secure engender muster revert incite motivate compel introduce elicit let evoke kindle occasion kickoff originate open break in cook up dream up make up work up lead to fire up result in think up ruin delay deter block hide halt stop close cover keep cause grounds interest justification rationale rationalization reason regard sake case claim lawsuit litigation proceeding prosecution suit activate animate arouse drive egg on energize excite impel influence inspire instigate key up mobilize move prompt propel put up to quicken rouse spur stimulate turn on work into lather channel factor force means medium organ power vehicle as long as being considering for for the reason that inasmuch as now seeing that since whereas antecedent assumption authority axiom backbone background backing base bedrock center chief ingredient core crux data dictum essence essential evidence explanation footing fundamental hard fact heart infrastructure keynote keystone law nexus nucleus postulate premise presumption presupposition principal element principle proof rudiment sanction security substratum support theorem theory underpinning warrant account action actuate agent 'cause blow stress ordeal torture agony shock wound damage strain injury anguish upset jolt hurt favor joy calm order peace help blast buffeting bump clash clout crack crash hit impact jar jarring jolting jounce pounding punch trauma big trouble catastrophe change climacteric climax confrontation contingency corner crossroad crunch crux culmination deadlock dilemma dire straits disaster embarrassment emergency entanglement exigency extremity height hot potato hour of decision imbroglio impasse juncture mess moment of truth necessity pass perplexity pickle pinch plight point of no return predicament pressure puzzle quandary situation stew strait trial trouble turning point urgency abrasion abuse affliction affront bad bite blemish boo-boo bruise burn chop cramp cut deformation detriment discomfiture disservice distress evil fracture gash grievance hemorrhage ill impairment indignity injustice insult laceration lesion libel loss mischief misery mutilation nick ouch outrage pang ruin scar scratch slander sore sprain stab sting suffering swelling twinge wrong awe bombshell breakdown collapse collision concussion confusion consternation disturbance double whammy earthquake encounter excitement eye-opener hysteria percussion prostration ram scare start stroke stupefaction stupor traumatism turn whammy wreck alarm albatross anxiety apprehensiveness burden clutch disquiet disquietude distention draw dread expectancy extension fear fearfulness ferment flutter force hardship hassle heat impatience intensity misgiving mistrust nervous tension nervousness oppression overextension passion protraction pull restlessness spring stretch tautness tenseness tension tensity tightness traction trepidation worry grief harm heartbreak pain slash torment crisis Trauma malady stroke Cancer defect virus fever plague bug fit attack blight spell canker ache upset misery flu health boon adversity anguish calamity cross crux depression difficulty disease disorder distress grief hardship illness infirmity misfortune ordeal pain plight scourge sickness sorrow suffering torment trial tribulation trouble woe complaint condition dose indisposition syndrome access ailment bout breakdown convulsion failure paroxysm relapse seizure spasm throe bacillus germ infection microbe big C carcinoma corruption long illness malignancy tumor affection ill affliction cancer Disease DisEASE division medicine analysis diagnosis inquiry cytology genetics etiology zoology histology connection ecology botany bioscience physics chemistry biology dissection embryology examination investigation morphology physiology animal biology anthropology biological science environmental science natural science science of life study of living things life sciences pure science science of matter anatomy life science Biology life amoebic anatomical animate basal biological biotic cellular constitutional elemental essential fundamental inherent innate integral live living necessary nuclear original plasmic primary prime primitive principal structural vital organic Whiteboard sketch satire drawing parody lampoon takeoff burlesque cartoon distortion farce imitation libel mimicry mockery pasquinade pastiche put-on ridicule send-up sham travesty Photostat Xerox carbon clone counterfeit delineate depict ditto draw dupe engrave engross fake forge imitate knock off limn manifold mimeo mirror mold paint paraphrase photocopy picture plagiarize portray reduplicate reflect repeat replicate represent reproduce rewrite sculpture simulate stat trace transcribe commercial art comp delineation depiction design doodle etching graphics layout likeness outline painting portrayal representation storyboard study tracing work of art comic comic-strip book manga adornment decoration engraving figure frontispiece halftone image line drawing photo photograph plate snapshot tailpiece vignette copy copycat dead ringer dummy duplicate effigy facsimile figurine game plan illustration knock-off look-alike miniature mock-up paste-up pocket portrait print relief ringer setup spitting image statue statuette visual caricature graphic novel model Cartoon
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